L
Lei Huang
Researcher at University of Chicago
Publications - 38
Citations - 1749
Lei Huang is an academic researcher from University of Chicago. The author has contributed to research in topics: Gene & Exome sequencing. The author has an hindex of 21, co-authored 38 publications receiving 1422 citations. Previous affiliations of Lei Huang include University of Illinois at Chicago.
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Journal ArticleDOI
Review of Current Methods, Applications, and Data Management for the Bioinformatics Analysis of Whole Exome Sequencing
TL;DR: This review focuses on established bioinformatics tools and applications that support five analytical steps: raw data quality assessment, preprocessing, alignment, post-processing, and variant analysis (detection, annotation, and prioritization).
Journal ArticleDOI
Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis
Sean P. Pitroda,Nikolai N. Khodarev,Lei Huang,Abhineet Uppal,Sean C. Wightman,Sabha Ganai,Nora E. Joseph,Jason J. Pitt,Miguel Brown,Martin Forde,Kathy A. Mangold,Lai Xue,Christopher R. Weber,Jeremy P. Segal,Sabah Kadri,Melinda E. Stack,Sajid A. Khan,Philip B. Paty,Karen L. Kaul,Jorge Andrade,Kevin P. White,Mark S. Talamonti,Mitchell C. Posner,Samuel Hellman,Ralph R. Weichselbaum +24 more
TL;DR: Three integrated molecular subtypes of colorectal cancer liver metastasis are identified, which complement clinical risk stratification to distinguish the subset of oligometastatic patients and provide a framework for integrated classification and treatment of metastasis.
Journal ArticleDOI
Tumor budding correlates with poor prognosis and epithelial-mesenchymal transition in tongue squamous cell carcinoma.
Cheng Wang,Hongzhang Huang,Zhiquan Huang,Anxun Wang,Xiaohua Chen,Lei Huang,Xiaofeng Zhou,Xiaofeng Zhou,Xiqiang Liu,Xiqiang Liu +9 more
TL;DR: Tumor budding, which associates with epithelial-mesenchymal transition, is a frequent event and appears to be an independent prognostic factor in TSCC.
Journal ArticleDOI
Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs.
Diana Rose E. Ranoa,A. Parekh,Sean P. Pitroda,Xiaona Huang,Thomas E. Darga,Anthony C. Wong,Lei Huang,Jorge Andrade,Jonathan P. Staley,Takashi Satoh,Shizuo Akira,Ralph R. Weichselbaum,Nikolai N. Khodarev +12 more
TL;DR: These findings suggest that the physiologic responses to radio-/chemo-therapy converge on an antiviral program in recruitment of the RLR pathway by a sncRNA-dependent activation of RIG-I which commences cytotoxic IFN signaling.
Journal ArticleDOI
14q32-encoded microRNAs mediate an oligometastatic phenotype
Abhineet Uppal,Sean C. Wightman,Stephen Mallon,Go Oshima,Sean P. Pitroda,Qingbei Zhang,Xiaona Huang,Thomas E. Darga,Lei Huang,Jorge Andrade,Huiping Liu,Mark K. Ferguson,Geoffrey L. Greene,Mitchell C. Posner,Samuel Hellman,Nikolai N. Khodarev,Ralph R. Weichselbaum +16 more
TL;DR: Understanding the role of microRNAs expressed in oligometastases may lead to improved identification of and interventions for patients with curable metastatic disease, as well as an improved understanding of the molecular basis of this unique clinical entity.