C
Caroline O.S. Savage
Researcher at University Hospitals Birmingham NHS Foundation Trust
Publications - 5
Citations - 193
Caroline O.S. Savage is an academic researcher from University Hospitals Birmingham NHS Foundation Trust. The author has contributed to research in topics: Vasculitis & Microscopic polyangiitis. The author has an hindex of 3, co-authored 5 publications receiving 180 citations.
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EULAR points to consider in the development of classifi cation and diagnostic criteria in systemic vasculitis
Neil Basu,Richard Watts,Ingeborg M. Bajema,Bo Baslund,Thorsten A. Bley,Paul A. Brogan,L. Calabrese,Maria C. Cid,Jan Willem Cohen-Tervaert,David Jayne,Cees G. M. Kallenberg,Xavier Puéchal,Niels Rasmussen,Alan D. Salama,Carlo Salvarani,Caroline O.S. Savage,David G. I. Scott,V. Tesar,Allan Wiik +18 more
TL;DR: Limitations in current classification criteria and definitions for vasculitis have been identified and suggestions provided for improvement and it is proposed that, in combination with the updated evidence, these should form the basis of future attempts to develop and validate revised criteria and definition of vasulitis.
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CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis
Lavanya Kamesh,Joanne Heward,Julie M. Williams,Stephen Gough,Konstantia-Maria Chavele,Alan D. Salama,Charles D. Pusey,Caroline O.S. Savage,Lorraine Harper +8 more
TL;DR: This study provides further evidence that CTLA-4, a susceptibility locus for a number of common autoimmune diseases, may also be involved in the development of ANCA-associated SVV.
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ANCA-associated vasculitis: from bench research to novel treatments
TL;DR: Small-vessel vasculitic syndromes such as Wegener granulomatosis and microscopic polyangiitis, which are associated with circulating antineutrophil cytoplasmic autoantibodies, and future potential therapies include molecules that block signaling pathways that are essential in the pathogenesis of these diseases.
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Medium Vessel Vasculitides
TL;DR: Clinical and histological findings were forgotten until descriptions of idiopathic, rapidly progressive glomerulo-nephritis led to the association of this disorder with microscopic polyangiitis, leading to the recognition of this as a form of renal-limited microvascular vasculitis.