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EULAR points to consider in the development of classifi cation and diagnostic criteria in systemic vasculitis
Neil Basu,Richard Watts,Ingeborg M. Bajema,Bo Baslund,Thorsten A. Bley,Paul A. Brogan,L. Calabrese,Maria C. Cid,Jan Willem Cohen-Tervaert,David Jayne,Cees G. M. Kallenberg,Xavier Puéchal,Niels Rasmussen,Alan D. Salama,Carlo Salvarani,Caroline O.S. Savage,David G. I. Scott,V. Tesar,Allan Wiik +18 more
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TLDR
Limitations in current classification criteria and definitions for vasculitis have been identified and suggestions provided for improvement and it is proposed that, in combination with the updated evidence, these should form the basis of future attempts to develop and validate revised criteria and definition of vasulitis.Abstract:
Objectives The systemic vasculitides are multiorgan diseases where early diagnosis and treatment can signifi cantly improve outcomes. Robust nomenclature reduces diagnostic delay. However, key aspects of current nomenclature are widely perceived to be out of date, these include disease defi nitions, classifi cation and diagnostic criteria. Therefore, the aim of the present work was to identify defi ciencies and provide contemporary points to consider for the development of future defi nitions and criteria in systemic vasculitis. Methods The expert panel identifi ed areas of concern within existing defi nitions/criteria. Consequently, a systematic literature review was undertaken looking to address these defi ciencies and produce ‘points to consider’ in accordance with standardised European League Against Rheumatism (EULAR) operating procedures. In the absence of evidence, expert consensus was used. Results There was unanimous consensus for re-evaluating existing defi nitions and developing new criteria. A total of 17 points to consider were proposed, covering 6 main areas: biopsy, laboratory testing, diagnostic radiology, nosology, defi nitions and research agenda. Suggestions to improve and expand current defi nitions were described including the incorporation of anti-neutrophil cytoplasm antibody and aetiological factors, where known. The importance of biopsy in diagnosis and exclusion of mimics was highlighted, while equally emphasising its problems. Thus, the role of alternative diagnostic tools such as MRI, ultrasound and surrogate markers were also discussed. Finally, structures to develop future criteria were considered. Conclusions Limitations in current classifi cation criteria and defi nitions for vasculitis have been identifi ed and suggestions provided for improvement. Additionally it is proposed that, in combination with the updated evidence, these should form the basis of future attempts to develop and validate revised criteria and defi nitions of vasculitis.read more
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Large vessel involvement in biopsy-proven giant cell arteritis: prospective study in 40 newly diagnosed patients using CT angiography
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Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis
Xavier Bossuyt,Jan Willem Cohen Tervaert,Yoshihiro Arimura,Daniel Engelbert Blockmans,Luis Felipe Flores-Suárez,Loïc Guillevin,Bernhard Hellmich,David Jayne,J. Charles Jennette,Cees G. M. Kallenberg,Sergey Moiseev,Pavel Novikov,Antonella Radice,Judith Savige,Renato Alberto Sinico,Ulrich Specks,Pieter van Paassen,Ming Hui Zhao,Niels Rasmussen,Jan Damoiseaux,Elena Csernok +20 more
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Comparison of the epidemiology of anti-neutrophil cytoplasmic antibody-associated vasculitis between Japan and the UK
Shouichi Fujimoto,Richard A. Watts,Shigeto Kobayashi,Kazuo Suzuki,David Jayne,David G. I. Scott,Hiroshi Hashimoto,Hiroyuki Nunoi +7 more
TL;DR: There was no major difference in AAV incidence between Japan and the U.K., but this prospective study found MPA and MPO-ANCA to be more common in Japan and granulomatosis with polyangiitis and PR3-AN CA to beMore common in theU.K, in line with earlier reports.
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ANCA-associated vasculitis - clinical utility of using ANCA specificity to classify patients.
TL;DR: Accumulating evidence suggests that ANCA specificity could be better than clinical diagnosis for defining homogeneous groups of patients, as PR3-ANCA and MPO-AnCA are associated with different genetic backgrounds and epidemiology.
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Diagnosis and classification of polyarteritis nodosa.
TL;DR: A recent consensus algorithm for the classification of PAN has attempted to overcome some of the caveats of the 1990 American College of Rheumatology classification criteria which have proven to be unsatisfactory, and has also confirmed the low prevalence of PAN compared to other systemic necrotizing vasculitides.
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EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee For International Clinical Studies Including Therapeutics (ESCISIT)
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TL;DR: 12 key recommendations for management of gout were developed, using a combination of research based evidence and expert consensus, based on a Delphi consensus approach.
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TL;DR: Criteria for the classification of polyarteritis nodosa were developed by comparing 118 patients who had this disease with 689 control Patients who had other forms of vasculitis.
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