C
Caroline Proulx
Researcher at North Carolina State University
Publications - 48
Citations - 1451
Caroline Proulx is an academic researcher from North Carolina State University. The author has contributed to research in topics: Peptoid & Peptide. The author has an hindex of 20, co-authored 43 publications receiving 1205 citations. Previous affiliations of Caroline Proulx include Université de Montréal & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
Peptoid nanosheets exhibit a new secondary-structure motif
Ranjan V. Mannige,Thomas K. Haxton,Caroline Proulx,Ellen J. Robertson,Alessia Battigelli,Glenn L. Butterfoss,Ronald N. Zuckermann,Stephen Whitelam +7 more
TL;DR: The authors' simulations show that nanosheets are structurally and dynamically heterogeneous, can be formed only from peptoids of certain lengths, and are potentially porous to water and ions, and the concept of building regular structures from multiple rotational states can be generalized beyond the peptoid nanosheet system.
Journal ArticleDOI
Design, Synthesis, Assembly, and Engineering of Peptoid Nanosheets
Ellen J. Robertson,Alessia Battigelli,Caroline Proulx,Ranjan V. Mannige,Thomas K. Haxton,Lisa Yun,Stephen Whitelam,Ronald N. Zuckermann +7 more
TL;DR: It is discovered that individual peptoid polymers with a simple sequence of alternating hydrophobic and ionic monomers can self-assemble into highly ordered, free-floating nanosheets, which provide a robust platform for the discovery of new classes of nanOSheets with tunable properties and novel applications.
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Azapeptides and their therapeutic potential.
Caroline Proulx,David Sabatino,David Sabatino,Robert Hopewell,Jochen Spiegel,Jochen Spiegel,Yesica Garcia Ramos,William D. Lubell +7 more
TL;DR: This review aims to provide a historical look at the development of azapeptide science along with a focus on recent developments and perspectives on the future of this useful tool for medicinal chemistry.
Journal ArticleDOI
Methylenation of Aldehydes: Transition Metal Catalyzed Formation of Salt-Free Phosphorus Ylides.
TL;DR: A variety of terminal alkenes are produced in excellent yields by the rhodium(I)-catalyzed methylenation of aldehydes using TMSCHN2 and PPh3 using mild reaction conditions.
Journal ArticleDOI
Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications.
TL;DR: A remarkable stride to overcome this bottleneck was made in 2009 through the introduction of the submonomer procedure for azapeptide synthesis, which enabled addition of diverse side chains onto a common semicarbazone intermediate, providing a means to construct azapePTide libraries by solution- and solid-phase chemistry.