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David Sabatino
Researcher at Seton Hall University
Publications - 33
Citations - 683
David Sabatino is an academic researcher from Seton Hall University. The author has contributed to research in topics: Peptide synthesis & Peptide. The author has an hindex of 11, co-authored 32 publications receiving 571 citations. Previous affiliations of David Sabatino include Université de Montréal.
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Journal ArticleDOI
Azapeptides and their therapeutic potential.
Caroline Proulx,David Sabatino,David Sabatino,Robert Hopewell,Jochen Spiegel,Jochen Spiegel,Yesica Garcia Ramos,William D. Lubell +7 more
TL;DR: This review aims to provide a historical look at the development of azapeptide science along with a focus on recent developments and perspectives on the future of this useful tool for medicinal chemistry.
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Peptide Scanning for Studying Structure-Activity Relationships in Drug Discovery
TL;DR: This critical commentary reviews scanning techniques, which employ natural and non‐proteinogenic amino acids to facilitate understanding of structural requirements for peptide biological activity, and highlights the value of sequence analysis by such methods.
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Exploring side-chain diversity by submonomer solid-phase aza-peptide synthesis.
David Sabatino,Caroline Proulx,Sophie Klocek,Carine B. Bourguet,Damien Boeglin,Huy Ong,William D. Lubell +6 more
TL;DR: Circular dichroism demonstrated that azaPhe-peptide 7a induced a beta-turn conformation which may be responsible for its 1000-fold improvement in GHRP-6 selectivity for the CD36 receptor.
Journal ArticleDOI
Structure-activity relationships of GHRP-6 azapeptide ligands of the CD36 scavenger receptor by solid-phase submonomer azapeptide synthesis.
TL;DR: The potential of introducing salt bridges to furnish GHRP-6 azapeptide ligands of the CD36 receptor with relatively high affinity is explored, considering that aromatic cation interactions may contribute to binding affinity.
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Solution-phase submonomer diversification of aza-dipeptide building blocks and their application in aza-peptide and aza-DKP synthesis.
TL;DR: A diversity‐oriented solution‐phase approach featuring alkylation of N‐terminal benzophenone semicarbazone aza‐Gly‐Xaa dipeptides using different alkyl halides in the presence of potassium tert‐butoxide as base may provide useful tools for studying peptide science.