C
Carolyn J. Brown
Researcher at University of British Columbia
Publications - 147
Citations - 14061
Carolyn J. Brown is an academic researcher from University of British Columbia. The author has contributed to research in topics: X-inactivation & X chromosome. The author has an hindex of 51, co-authored 139 publications receiving 12837 citations. Previous affiliations of Carolyn J. Brown include Max Planck Society & BC Cancer Research Centre.
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Journal ArticleDOI
Derivation of consensus inactivation status for X-linked genes from genome-wide studies
TL;DR: This analysis aggregated three published studies that have examined X chromosome inactivation status of genes across the X chromosome, generating consensus calls and identifying discordancies to compile a comprehensive list of X-chromosome inactivation statuses for genes.
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Acquired TNFRSF14 Mutations in Follicular Lymphoma Are Associated with Worse Prognosis
K-John Cheung,Nathalie A. Johnson,Joslynn G. Affleck,Tesa M. Severson,Christian Steidl,Susana Ben-Neriah,Jacqueline E. Schein,Ryan D. Morin,Richard D. Moore,Sohrab P. Shah,Hong Qian,Jessica E. Paul,Adele Telenius,Thomas Relander,Wan L. Lam,Kerry J. Savage,Joseph M. Connors,Carolyn J. Brown,Marco A. Marra,Randy D. Gascoyne,Douglas E. Horsman +20 more
TL;DR: TNFRSF14 is identified as a candidate gene associated with a subset of FL, based on frequent occurrence of acquired mutations and their correlation with inferior clinical outcomes, and its association with inferior OS and DSS is identified.
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A stain upon the silence: genes escaping X inactivation
Carolyn J. Brown,John M. Greally +1 more
TL;DR: The causes and consequences of failure to silence the entire X chromosome are examined, the impact of the evolutionary history of the X (and Y) chromosome is discussed, and the bioinformatic approaches that promise to provide new insights into the genomic architecture of genes or regions that escape X-chromosome inactivation are discussed.
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The dynamics of X-inactivation skewing as women age.
C. Hatakeyama,Catherine L. Anderson,C. L. Beever,Maria S. Peñaherrera,Carolyn J. Brown,Wendy P. Robinson +5 more
TL;DR: A weak but significant positive correlation was observed between age and degree of skewing in XCI over the whole age range, and skewing values become non‐normally distributed at older ages, supporting the model of increased skewing with age as a consequence of hematopoietic stem cell senescence.
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Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology
Victor D. Martinez,Emily A. Vucic,Kelsie L. Thu,Roland Hubaux,Katey S. S. Enfield,Larissa A. Pikor,Daiana D. Becker-Santos,Carolyn J. Brown,Stephen Lam,Wan L. Lam +9 more
TL;DR: It is shown that piRNA expression can delineate clinical features, such as histological subgroups, disease stages, and survival, and be able to distinguish tissue-of-origin from non-malignant tissues in a cancer-type specific manner.