Journal ArticleDOI
A stain upon the silence: genes escaping X inactivation
Carolyn J. Brown,John M. Greally +1 more
TLDR
The causes and consequences of failure to silence the entire X chromosome are examined, the impact of the evolutionary history of the X (and Y) chromosome is discussed, and the bioinformatic approaches that promise to provide new insights into the genomic architecture of genes or regions that escape X-chromosome inactivation are discussed.About:
This article is published in Trends in Genetics.The article was published on 2003-08-01. It has received 160 citations till now. The article focuses on the topics: XIST & X-inactivation.read more
Citations
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Journal ArticleDOI
X-inactivation profile reveals extensive variability in X-linked gene expression in females
TL;DR: A comprehensive X-inactivation profile of the human X chromosome is presented, representing an estimated 95% of assayable genes in fibroblast-based test systems, and suggests a remarkable and previously unsuspected degree of expression heterogeneity among females.
Journal ArticleDOI
Cost of lost productive work time among US workers with depression.
TL;DR: The combined LPT burden among those with depression and the low level of treatment suggests that there may be cost-effective opportunities for improving depression-related outcomes in the US workforce.
Journal ArticleDOI
The evolution of sex-biased genes and sex-biased gene expression.
Hans Ellegren,John Parsch +1 more
TL;DR: The characteristics and expression of sex-biased genes, and the selective forces that shape this previously unappreciated source of phenotypic diversity, are discussed.
Journal ArticleDOI
A census of mammalian imprinting
TL;DR: There is a high level of discordance of imprinting status between the mouse and human, even when cases in which the orthologue is absent from one species are excluded, and a high proportion of imprinted genes are noncoding RNAs or genes derived by retrotransposition.
Journal ArticleDOI
Dosage compensation in mammals: fine-tuning the expression of the X chromosome
TL;DR: The discovery and possible implications of a second form of dosage compensation in mammals that deals with the unique, potentially haploinsufficient, status of the X chromosome with respect to autosomal gene expression are reviewed.
References
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Journal ArticleDOI
Gene Action in the X -chromosome of the Mouse ( Mus musculus L.)
TL;DR: Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome.
Journal ArticleDOI
Four Evolutionary Strata on the Human X Chromosome
Bruce T. Lahn,David C. Page +1 more
TL;DR: The ages of individual X-Y gene pairs and the locations of their X members on the X chromosome were found to be highly correlated and age decreased in stepwise fashion from thedistal long arm to the distal short arm in at least four "evolutionary strata".
Journal ArticleDOI
The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression
Peter Jeppesen,Bryan M. Turner +1 more
TL;DR: In this paper, immunolabeled human and mouse metaphase chromosomes with antibodies specific for the acetylated isoforms of histone H4 were labeled in regions corresponding to conventional R bands (regions enriched in coding DNA), except for a single chromosome in female cells.
PatentDOI
Allelic variation in human gene expression
TL;DR: Genetically-determined variation in expression levels is an important component of human diversity and has significant implications for normal and abnormal human physiology using this genetically determined variation one can identify disease risk factors in individuals as mentioned in this paper.
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