C
Carolyne Horner
Researcher at British Society for Antimicrobial Chemotherapy
Publications - 33
Citations - 1073
Carolyne Horner is an academic researcher from British Society for Antimicrobial Chemotherapy. The author has contributed to research in topics: Population & Methicillin-resistant Staphylococcus aureus. The author has an hindex of 14, co-authored 31 publications receiving 731 citations. Previous affiliations of Carolyne Horner include Public Health England & Leeds Teaching Hospitals NHS Trust.
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Journal ArticleDOI
Reduced susceptibility to chlorhexidine in staphylococci: is it increasing and does it matter?
TL;DR: The development of reduced susceptibility to chlorhexidine and the presence of efflux-mediated resistance genes in staphylococci are focused on, and the clinical significance of this phenomenon is reviewed.
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One Health Genomic Surveillance of Escherichia coli Demonstrates Distinct Lineages and Mobile Genetic Elements in Isolates from Humans versus Livestock.
Catherine Ludden,Catherine Ludden,Kathy E. Raven,Dorota Jamrozy,Theodore Gouliouris,Theodore Gouliouris,Theodore Gouliouris,Beth Blane,Francesc Coll,Francesc Coll,Marcus C. de Goffau,Plamena Naydenova,Carolyne Horner,Juan Hernandez-Garcia,Paul Wood,Nazreen F. Hadjirin,Milorad Radakovic,Nicholas M. Brown,Nicholas M. Brown,Nicholas M. Brown,Mark A. Holmes,Julian Parkhill,Sharon J. Peacock,Sharon J. Peacock,Sharon J. Peacock +24 more
TL;DR: There was limited evidence that antimicrobial-resistant pathogens associated with serious human infection had originated from livestock in the authors' region, according to analysis of mobile genetic elements and long-read sequencing.
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Diversification of Colonization Factors in a Multidrug-Resistant Escherichia coli Lineage Evolving under Negative Frequency-Dependent Selection.
Alan McNally,Teemu Kallonen,Teemu Kallonen,Christopher Connor,Khalil Abudahab,David M. Aanensen,Carolyne Horner,Sharon J. Peacock,Sharon J. Peacock,Sharon J. Peacock,Julian Parkhill,Nicholas J. Croucher,Jukka Corander,Jukka Corander,Jukka Corander +14 more
TL;DR: A detailed population genomic analysis of the ExPEC ST131 clone is presented, in which it is shown that negative frequency-dependent selection acting across accessory loci is a major mechanism that has shaped the population evolution of this pathogen.
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Escherichia coli bacteraemia: 2 years of prospective regional surveillance (2010–12)
Carolyne Horner,W. N. Fawley,K. Morris,P. Parnell,M. Denton,M. Denton,Mark H. Wilcox,Mark H. Wilcox +7 more
TL;DR: The variable prevalence of resistance to amoxicillin/clavulanic acid raises concerns, as both E. coli bacteraemia and empirical use of this antibiotic are common.
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Genomic Surveillance of Enterococcus faecium Reveals Limited Sharing of Strains and Resistance Genes between Livestock and Humans in the United Kingdom
Theodore Gouliouris,Theodore Gouliouris,Kathy E. Raven,Catherine Ludden,Beth Blane,Jukka Corander,Jukka Corander,Carolyne Horner,Juan Hernandez-Garcia,Paul Wood,Nazreen F. Hadjirin,Milorad Radakovic,Mark A. Holmes,Marcus C. de Goffau,Nicholas M. Brown,Julian Parkhill,Sharon J. Peacock,Sharon J. Peacock,Sharon J. Peacock +18 more
TL;DR: The first livestock VREfm prevalence survey in the UK since 2003 and the first large-scale study using whole-genome sequencing to investigate the relationship between E. faecium strains in livestock and humans found a low prevalence of VRE FM in retail meat and limited evidence for recent sharing of strains between livestock and human with bloodstream infection.