C
Carrie Lin
Researcher at Boston Children's Hospital
Publications - 4
Citations - 553
Carrie Lin is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Enhancer & Transcription factor. The author has an hindex of 3, co-authored 3 publications receiving 471 citations. Previous affiliations of Carrie Lin include Harvard University.
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Journal ArticleDOI
An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level
Daniel E. Bauer,Sophia C. Kamran,Sophia C. Kamran,Samuel Lessard,Jian Xu,Jian Xu,Yuko Fujiwara,Carrie Lin,Zhen Shao,Matthew C. Canver,Elenoe C. Smith,Luca Pinello,Peter J. Sabo,Jeff Vierstra,Richard A. Voit,Guo-Cheng Yuan,Matthew H. Porteus,John A. Stamatoyannopoulos,Guillaume Lettre,Stuart H. Orkin +19 more
TL;DR: It is found that common genetic variation at BCL11A associated with fetal hemoglobin (HbF) level lies in noncoding sequences decorated by an erythroid enhancer chromatin signature, illustrating how GWASs may expose functional variants of modest impact within causal elements essential for appropriate gene expression.
Journal ArticleDOI
Fine-Mapping and Genome Editing Reveal An Essential Erythroid Enhancer At The HbF-Associated BCL11A Locus
Daniel E. Bauer,Sophia C. Kamran,Samuel Lessard,Jian Xu,Yuko Fujiwara,Carrie Lin,Zhen Shao,Matthew C. Canver,Elenoe C. Smith,Luca Pinello,Peter J. Sabo,Jeff Vierstra,Richard A. Voit,Guo-Cheng Yuan,Matthew H. Porteus,John A. Stamatoyannopoulos,Guillaume Lettre,Stuart H. Orkin +17 more
TL;DR: The results validate the hypothesis that common variation modulates cell type-specific regulatory elements, and reveal that although functional variants themselves may be of modest impact, their harboring elements may be critical for appropriate gene expression.
Journal ArticleDOI
HbF-Associated Genetic Variation Marks an Erythroid Regulatory Element Essential for BCL11A Transcription and Subsequent Stage-Specific Globin Expression
Daniel E. Bauer,Sophia C. Kamran,Jian Xu,Carrie Lin,Zhen Shao,Yuko Fujiwara,Richard A. Voit,Matthew H. Porteus,John A. Stamatoyannopoulos,Stuart H. Orkin +9 more
TL;DR: HbF-associated genetic variation in BCL 11A modulates the function of a critical erythroid enhancer of BCL11A, and consequently expression of B CL11A itself is regulated, demonstrating the importance of quantitative level expression in the regulation of the stage-specific globin genes.
Posted ContentDOI
Plasmodium falciparum exploits CD44 as a co-receptor for erythrocyte invasion
Chi Yong Kim,Carrie Lin,Angel K. Kongsomboonvech,Marilou Tétard,Nichole D. Salinas,Niraj H. Tolia,Elizabeth S. Egan +6 more
TL;DR: In this article , the authors found that CD44 can be efficiently deleted from primary human hematopoietic stem cells using CRISPR/Cas9 genome editing, and that the efficiency of ex-vivo erythropoiesis to enucleated cultured red blood cells (cRBCs) is not impacted by lack of CD44.