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Daniel E. Bauer
Researcher at Harvard University
Publications - 166
Citations - 16582
Daniel E. Bauer is an academic researcher from Harvard University. The author has contributed to research in topics: Genome editing & Gene. The author has an hindex of 46, co-authored 147 publications receiving 13380 citations. Previous affiliations of Daniel E. Bauer include Dana Corporation & Broad Institute.
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Journal ArticleDOI
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
Julian J. Lum,Daniel E. Bauer,Mei Kong,Marian H. Harris,Chi Li,Tullia Lindsten,Craig B. Thompson +6 more
TL;DR: Using growth factor-dependent cells from Bax/Bak-deficient mice, it is demonstrated that apoptosis is not essential to limit cell autonomous survival and growth factor signal transduction is required to direct the utilization of sufficient exogenous nutrients to maintain cell viability.
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Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques
Xia Jin,Daniel E. Bauer,Sarah Tuttleton,Sharon R Lewin,Agegnehu Gettie,James Blanchard,Craig E. Irwin,Jeffrey T. Safrit,John E. Mittler,Leor S. Weinberger,Leondios G. Kostrikis,Linqi Zhang,Alan S. Perelson,David D. Ho +13 more
TL;DR: It is demonstrated that CD8 cells play a crucial role in suppressing SIV replication in vivo and are examined using an anti-CD8 monoclonal antibody, OKT8F.
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Akt stimulates aerobic glycolysis in cancer cells
Rebecca Elstrom,Daniel E. Bauer,Monica Buzzai,Robyn Karnauskas,Marian H. Harris,David R. Plas,Hongming Zhuang,Ryan M. Cinalli,Abass Alavi,Charles M. Rudin,Craig B. Thompson +10 more
TL;DR: It is suggested that activation of the Akt oncogene is sufficient to stimulate the switch to aerobic glycolysis characteristic of cancer cells and that Akt activity renders cancer cells dependent on aerobic glyCOlysis for continued growth and survival.
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ATP citrate lyase inhibition can suppress tumor cell growth
Georgia Hatzivassiliou,Fangping Zhao,Daniel E. Bauer,Charalambos Andreadis,Shaw Antony N,Dashyant Dhanak,Sunil R. Hingorani,David A. Tuveson,Craig B. Thompson +8 more
TL;DR: ACL inhibition by RNAi or the chemical inhibitor SB-204990 limits in vitro proliferation and survival of tumor cells displaying aerobic glycolysis, and these treatments also reduce in vivo tumor growth and induce differentiation.
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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Matthew C. Canver,Elenoe C. Smith,Falak Sher,Luca Pinello,Neville E. Sanjana,Ophir Shalem,Diane D. Chen,Patrick G. Schupp,Divya S. Vinjamur,Sara P. Garcia,Sidinh Luc,Ryo Kurita,Yukio Nakamura,Yuko Fujiwara,Yuko Fujiwara,Takahiro Maeda,Guo-Cheng Yuan,Feng Zhang,Stuart H. Orkin,Stuart H. Orkin,Daniel E. Bauer +20 more
TL;DR: A pooled clustered regularly interspaced palindromic repeat-Cas9 guide RNA libraries are developed to perform in situ saturating mutagenesis of the human and mouse enhancers and reveal critical minimal features and discrete vulnerabilities of these enhancers.