E
Elenoe C. Smith
Researcher at Harvard University
Publications - 16
Citations - 1821
Elenoe C. Smith is an academic researcher from Harvard University. The author has contributed to research in topics: Enhancer & Gene. The author has an hindex of 11, co-authored 14 publications receiving 1467 citations. Previous affiliations of Elenoe C. Smith include Yale University & Boston Children's Hospital.
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Journal ArticleDOI
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Matthew C. Canver,Elenoe C. Smith,Falak Sher,Luca Pinello,Neville E. Sanjana,Ophir Shalem,Diane D. Chen,Patrick G. Schupp,Divya S. Vinjamur,Sara P. Garcia,Sidinh Luc,Ryo Kurita,Yukio Nakamura,Yuko Fujiwara,Yuko Fujiwara,Takahiro Maeda,Guo-Cheng Yuan,Feng Zhang,Stuart H. Orkin,Stuart H. Orkin,Daniel E. Bauer +20 more
TL;DR: A pooled clustered regularly interspaced palindromic repeat-Cas9 guide RNA libraries are developed to perform in situ saturating mutagenesis of the human and mouse enhancers and reveal critical minimal features and discrete vulnerabilities of these enhancers.
Journal ArticleDOI
An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level
Daniel E. Bauer,Sophia C. Kamran,Sophia C. Kamran,Samuel Lessard,Jian Xu,Jian Xu,Yuko Fujiwara,Carrie Lin,Zhen Shao,Matthew C. Canver,Elenoe C. Smith,Luca Pinello,Peter J. Sabo,Jeff Vierstra,Richard A. Voit,Guo-Cheng Yuan,Matthew H. Porteus,John A. Stamatoyannopoulos,Guillaume Lettre,Stuart H. Orkin +19 more
TL;DR: It is found that common genetic variation at BCL11A associated with fetal hemoglobin (HbF) level lies in noncoding sequences decorated by an erythroid enhancer chromatin signature, illustrating how GWASs may expose functional variants of modest impact within causal elements essential for appropriate gene expression.
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Matthew C. Canver,Elenoe C. Smith,Falak Sher,Luca Pinello,Neville E. Sanjana,Ophir Shalem,Diane D. Chen,Patrick G. Schupp,Divya S. Vinjamur,Sara P. Garcia,Sidinh Luc,Ryo Kurita,Yukio Nakamura,Yuko Fujiwara,Yuko Fujiwara,Takahiro Maeda,Guo-Cheng Yuan,Feng Zhang,Stuart H. Orkin,Stuart H. Orkin,Daniel E. Bauer +20 more
TL;DR: The authors developed pooled clustered regularly interspaced palindromic repeat (CRISPR)-Cas9 guide RNA libraries to perform in situ saturating mutagenesis of the human and mouse enhancers.
Journal ArticleDOI
ProxTom lymphatic vessel reporter mice reveal Prox1 expression in the adrenal medulla, megakaryocytes, and platelets.
Lucy A. Truman,Kevin L. Bentley,Elenoe C. Smith,Stephanie A. Massaro,David Gonzalez,Ann M. Haberman,Myriam Hill,Dennis Jones,Wang Min,Diane S. Krause,Nancy H. Ruddle +10 more
TL;DR: The faithful expression of the fluorescent reporter in ProxTom LVs indicates that these mice have potential utility in the study of diseases as diverse as lymphedema, filariasis, transplant rejection, obesity, and tumor metastasis.
Journal ArticleDOI
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.
Yuan Gao,Elenoe C. Smith,Elmer Ker,Phil G. Campbell,Ee-chun Cheng,Siying Zou,Sharon Lin,Lin Wang,Stephanie Halene,Diane S. Krause +9 more
TL;DR: Using primary cells, it is demonstrated that the guanine exchange factors GEF-H1 and ECT2, which are often overexpressed in cancer and are essential for RhoA activation during cytokinesis, must be downregulated for Mk polyploidization.