N
Nikolaus Plesnila
Researcher at Ludwig Maximilian University of Munich
Publications - 178
Citations - 8432
Nikolaus Plesnila is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Traumatic brain injury & Ischemia. The author has an hindex of 46, co-authored 162 publications receiving 7350 citations. Previous affiliations of Nikolaus Plesnila include Max Planck Society & Harvard University.
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Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death
Alexander Seiler,Manuela Schneider,Heidi Förster,Stephan Roth,Eva K. Wirth,Carsten Culmsee,Nikolaus Plesnila,Elisabeth Kremmer,Olof Rådmark,Wolfgang Wurst,Georg W. Bornkamm,Ulrich Schweizer,Marcus Conrad +12 more
TL;DR: It is demonstrated that oxidative stress is sensed and transduced by glutathione peroxidase 4 (GPx4) into a-yet-unrecognized cell-death pathway, and the identified pathway reveals promising targets for future therapies.
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Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
Swetlana Sirko,Gwendolyn Behrendt,Pia A Johansson,Pratibha Tripathi,Marcos R. Costa,Sarah Bek,Christophe Heinrich,Steffen Tiedt,Dilek Colak,Martin Dichgans,Isabel Rebekka Fischer,Nikolaus Plesnila,Matthias Staufenbiel,Christian Haass,Christian Haass,Marina Snapyan,Armen Saghatelyan,Li-Huei Tsai,Li-Huei Tsai,Andre Fischer,Kay Grobe,Leda Dimou,Magdalena Götz +22 more
TL;DR: These findings provide a molecular basis for how cells with neural stem cell lineage emerge at sites of brain injury and imply that the high levels of SHH known to enter the brain from extraneural sources after invasive injury can trigger this response.
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Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia
Carsten Culmsee,Changlian Zhu,Stefan Landshamer,Barbara Becattini,Ernst Wagner,Maurizio Pellecchia,Klas Blomgren,Nikolaus Plesnila +7 more
TL;DR: Results provide the first evidence for a causal role of AIF in ischemic neuronal cell death and suggest caspase-independent cell death signaling may provide a promising novel target for therapeutic interventions in cerebrovascular diseases.
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Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation
Dean A. Le,Yongqin Wu,Zhihong Huang,Kohji Matsushita,Nikolaus Plesnila,Jean C. Augustinack,Bradley T. Hyman,Junying Yuan,Keisuke Kuida,Richard A. Flavell,Michael A. Moskowitz +10 more
TL;DR: The present study found that caspase-8 mediated poly(ADP-ribose) polymerase cleavage in caspasase-3−/− neurons in vivo and in vitro, and indicates the potential advantages of targeting more than a single caspases family member to treat ischemic cell injury.
Journal ArticleDOI
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia
Nikolaus Plesnila,Sandra S. Zinkel,Dean A. Le,Sepideh Amin-Hanjani,Yonqin Wu,Jianhua Qiu,Alberto Chiarugi,Sunu S. Thomas,Daniel S. Kohane,Stanley J. Korsmeyer,Michael A. Moskowitz +10 more
TL;DR: The findings suggest that BID and the mitochondrial-amplification pathway promoting caspase activation contributes importantly to neuronal cell death after ischemic insult.