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Carsten Korth
Researcher at University of Düsseldorf
Publications - 146
Citations - 5230
Carsten Korth is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: DISC1 & Amyloid beta. The author has an hindex of 39, co-authored 139 publications receiving 4441 citations. Previous affiliations of Carsten Korth include University of California, San Francisco & Forschungszentrum Jülich.
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Journal ArticleDOI
Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease
TL;DR: It is reported here that tricyclic derivatives of acridine and phenothiazine exhibit half-maximal inhibition of PrPSc formation at effective concentrations (EC50) between 0.3 μM and 3 μM in cultured cells chronically infected with prions.
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SARS-CoV-2 targets neurons of 3D human brain organoids.
Anand Ramani,Lisa Müller,Philipp Niklas Ostermann,Elke Gabriel,Pranty Abida‐Islam,Andreas Müller-Schiffmann,Aruljothi Mariappan,Olivier Goureau,Henning Gruell,Andreas Walker,Marcel Andree,Sandra Hauka,Torsten Houwaart,Alexander T. Dilthey,Kai Wohlgemuth,Heymut Omran,Florian Klein,Dagmar Wieczorek,Ortwin Adams,Jörg Timm,Carsten Korth,Heiner Schaal,Jay Gopalakrishnan +22 more
TL;DR: Imaging neurons of organoids reveal that SARS‐CoV‐2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death, and these studies provide initial insights into the potential neurotoxic effect of Sars‐Cov‐2.
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Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier
Steffen E. Storck,Sabrina Meister,Julius Nahrath,Julius N. Meißner,Nils Schubert,Alessandro Di Spiezio,Sandra Baches,Roosmarijn E. Vandenbroucke,Yvonne Bouter,Ingrid Prikulis,Carsten Korth,Sascha Weggen,Axel Heimann,Markus Schwaninger,Thomas A. Bayer,Claus U. Pietrzik +15 more
TL;DR: Transgenic mouse strains that allow for tamoxifen-inducible deletion of Lrp1 specifically within brain endothelial cells are developed and used and suggest that receptor-mediated Aβ BBB clearance may be a potential target for treatment and prevention of Aβ brain accumulation in AD.
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Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development
Nicholas J. Brandon,J. Kirsty Millar,Carsten Korth,Hazel Sive,Hazel Sive,Karun K. Singh,Akira Sawa +6 more
TL;DR: A number of exciting areas of current DISC1 research are revealed that are revealing roles for DISC 1 during normal brain development and also in the disease state, which will provide a timely and exciting overview of the field and its potential in furthering the understanding of psychiatric diseases and in developing new therapies.
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Rapidly Progressive Alzheimer Disease
TL;DR: An overview of the current knowledge of rapidly progressive Alzheimer disease is provided and it is suggested that rapid, in this context, should be defined as a Mini-Mental State Examination score decrease of 6 points per year.