H
Henning Gruell
Researcher at University of Cologne
Publications - 86
Citations - 4373
Henning Gruell is an academic researcher from University of Cologne. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 21, co-authored 62 publications receiving 2318 citations. Previous affiliations of Henning Gruell include Rockefeller University & University of Münster.
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Journal ArticleDOI
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
Florian Klein,Ariel Halper-Stromberg,Joshua A. Horwitz,Henning Gruell,Henning Gruell,Johannes F. Scheid,Johannes F. Scheid,Stylianos Bournazos,Hugo Mouquet,Linda Spatz,Linda Spatz,Ron Diskin,Alexander Abadir,Trinity Zang,Marcus Dorner,Eva Billerbeck,Rachael N. Labitt,Christian Gaebler,Christian Gaebler,Paola Marcovecchio,Reha Baris Incesu,Thomas Eisenreich,Paul D. Bieniasz,Paul D. Bieniasz,Michael S. Seaman,Pamela J. Bjorkman,Jeffrey V. Ravetch,Alexander Ploss,Michel C. Nussenzweig,Michel C. Nussenzweig +29 more
TL;DR: Combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV- 1-infected individuals.
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Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study.
Max Augustin,Philipp Schommers,Melanie Stecher,Felix Dewald,Lutz Gieselmann,Henning Gruell,Carola Horn,Kanika Vanshylla,Veronica Di Cristanziano,Luise Osebold,Maria Roventa,Toqeer Riaz,Nikolai Tschernoster,Janine Altmueller,Leonard Rose,Susanne Salomon,Vanessa Priesner,Jan Christoffer Luers,Christian Albus,Stephan Rosenkranz,Birgit S. Gathof,Gerd Fätkenheuer,Michael Hallek,Florian Klein,Isabelle Suárez,Clara Lehmann +25 more
TL;DR: The on-going presence of either shortness of breath, anosmia, ageusia or fatigue as long-lasting symptoms even in non-hospitalised patients was observed at four and seven months post-infection and summarised as post-COVID syndrome (PCS).
Journal ArticleDOI
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals
Marina Caskey,Till Schoofs,Henning Gruell,Allison Settler,Theodora K. Karagounis,Edward F. Kreider,Ben Murrell,Nico Pfeifer,Lilian Nogueira,Thiago Y. Oliveira,Gerald H. Learn,Yehuda Z. Cohen,Clara Lehmann,Daniel Gillor,Irina Shimeliovich,Cecilia Unson-O’Brien,Daniela Weiland,Alexander. Robles,Tim Kümmerle,Christoph Wyen,Rebeka Levin,Maggi Witmer-Pack,Kemal Eren,Caroline Ignacio,Szilard Kiss,Anthony P. West,Hugo Mouquet,Barry S. Zingman,Barry S. Zingman,Roy M. Gulick,Tibor Keler,Pamela J. Bjorkman,Michael S. Seaman,Beatrice H. Hahn,Gerd Fätkenheuer,Sarah J. Schlesinger,Michel C. Nussenzweig,Michel C. Nussenzweig,Florian Klein +38 more
TL;DR: The results demonstrate the safety and activity of 10-1074 in humans and support the idea that antibodies targeting the V3 glycan supersite might be useful for the treatment and prevention of HIV-1 infection.
Journal ArticleDOI
Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Pilar Mendoza,Henning Gruell,Lilian Nogueira,Joy A. Pai,Allison L. Butler,Katrina G. Millard,Clara Lehmann,Isabelle Suárez,Thiago Y. Oliveira,Julio C. C. Lorenzi,Yehuda Z. Cohen,Christoph Wyen,Christoph Wyen,Tim Kümmerle,Tim Kümmerle,Theodora K. Karagounis,Ching-Lan Lu,Lisa Handl,Cecilia Unson-O’Brien,Roshni Patel,Carola Ruping,Maike Schlotz,Maggi Witmer-Pack,Irina Shimeliovich,Gisela Kremer,Eleonore Thomas,Kelly E. Seaton,Jill Horowitz,Anthony P. West,Pamela J. Bjorkman,Georgia D. Tomaras,Roy M. Gulick,Nico Pfeifer,Gerd Fätkenheuer,Michael S. Seaman,Florian Klein,Marina Caskey,Michel C. Nussenzweig,Michel C. Nussenzweig +38 more
TL;DR: It is concluded that the combination of the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 can maintain long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.
Journal ArticleDOI
SARS-CoV-2 targets neurons of 3D human brain organoids.
Anand Ramani,Lisa Müller,Philipp Niklas Ostermann,Elke Gabriel,Pranty Abida‐Islam,Andreas Müller-Schiffmann,Aruljothi Mariappan,Olivier Goureau,Henning Gruell,Andreas Walker,Marcel Andree,Sandra Hauka,Torsten Houwaart,Alexander T. Dilthey,Kai Wohlgemuth,Heymut Omran,Florian Klein,Dagmar Wieczorek,Ortwin Adams,Jörg Timm,Carsten Korth,Heiner Schaal,Jay Gopalakrishnan +22 more
TL;DR: Imaging neurons of organoids reveal that SARS‐CoV‐2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death, and these studies provide initial insights into the potential neurotoxic effect of Sars‐Cov‐2.