C
Cary T. Valley
Researcher at University of Wisconsin-Madison
Publications - 3
Citations - 233
Cary T. Valley is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Riboswitch & RNA. The author has an hindex of 3, co-authored 3 publications receiving 216 citations.
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Journal ArticleDOI
Cooperativity in RNA-Protein Interactions: Global Analysis of RNA Binding Specificity
Zachary T. Campbell,Devesh Bhimsaria,Cary T. Valley,José A. Rodríguez-Martínez,Elena Menichelli,James R. Williamson,Aseem Z. Ansari,Marvin Wickens +7 more
TL;DR: A method for global unbiased analysis of RNA-protein interactions that uses in vitro selection, high-throughput sequencing, and sequence-specificity landscapes is described that yields affinities for a vast array of RNAs in a single experiment, including both low- and high-affinity sites.
Journal ArticleDOI
A protein-RNA specificity code enables targeted activation of an endogenous human transcript
TL;DR: This study designed a protein that targets endogenous cyclin B1 mRNA in human cells, increasing sensitivity to chemotherapeutic drugs and provides a guide for rational design of engineered mRNA control, including translational stimulation.
Journal ArticleDOI
Patterns and plasticity in RNA-protein interactions enable recruitment of multiple proteins through a single site
Cary T. Valley,Douglas F. Porter,Chen Qiu,Zachary T. Campbell,Traci M. Tanaka Hall,Marvin Wickens +5 more
TL;DR: It is shown that despite these differences, the pattern of RNA interactions is conserved among PUF proteins: the two ends of the PUF protein make critical contacts with the two Ends of the RNA sites, a conserved “two-handed” pattern of recognition.