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Aseem Z. Ansari
Researcher at University of Wisconsin-Madison
Publications - 85
Citations - 6211
Aseem Z. Ansari is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Transcription (biology) & RNA polymerase II. The author has an hindex of 40, co-authored 82 publications receiving 5802 citations. Previous affiliations of Aseem Z. Ansari include Memorial Sloan Kettering Cancer Center & Harvard University.
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Journal ArticleDOI
A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters.
Gwenael Badis,Esther T. Chan,Harm van Bakel,Lourdes Peña-Castillo,Desiree Tillo,Kyle Tsui,Clayton D. Carlson,Andrea J. Gossett,Michael J. Hasinoff,Christopher L. Warren,Marinella Gebbia,Shaheynoor Talukder,Ally Yang,Sanie Mnaimneh,Dimitri Terterov,David Coburn,Ai Li Yeo,Zhen Xuan Yeo,Neil D. Clarke,Jason D. Lieb,Aseem Z. Ansari,Corey Nislow,Timothy P. Hughes +22 more
TL;DR: Systematic determination of yeast transcription factor DNA-binding specificities shows that Rsc3 plays a broad role in targeting nucleosome exclusion at yeast promoters, suggesting a role in promoter architecture.
Journal ArticleDOI
Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase.
Eric J. Steinmetz,Christopher L. Warren,Jason N. Kuehner,Bahman Panbehi,Aseem Z. Ansari,David A. Brow +5 more
TL;DR: A high-resolution map of Pol II occupancy across the entire yeast genome is presented, suggesting that progressive neurological disorders caused by substitutions in the human Sen1 homolog Senataxin may be due to misregulation of transcription.
Journal ArticleDOI
TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.
Md. Sohail Akhtar,Martin Heidemann,Joshua R. Tietjen,David W. Zhang,Rob D. Chapman,Dirk Eick,Aseem Z. Ansari +6 more
TL;DR: The results implicate the TFIIH kinase in placing bivalent Ser5 and Ser7 marks early in gene transcription, which specify the cotranscriptional engagement of the relevant RNA processing machinery.
Journal ArticleDOI
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Henri Marc Bourbon,Andrés Aguilera,Aseem Z. Ansari,Francisco J. Asturias,Arnold J. Berk,Stefan Björklund,T. Keith Blackwell,Tilman Borggrefe,Michael Carey,Marian Carlson,Joan W. Conaway,Ronald C. Conaway,Scott W. Emmons,Joseph D. Fondell,Leonard P. Freedman,Toshio Fukasawa,Claes M. Gustafsson,Min Han,Xi He,Paul K. Herman,Alan G. Hinnebusch,Steen Holmberg,Frank C. P. Holstege,Judith A. Jaehning,Young Joon Kim,Laurent Kuras,Achim Leutz,John T. Lis,Michael Meisterernest,Anders M. Näär,Kim Nasmyth,Jeffrey D. Parvin,Mark Ptashne,Danny Reinberg,Hans Ronne,Hans Ronne,Ivan Sadowski,Hiroshi Sakurai,Matthias Sipiczki,Paul W. Sternberg,David J. Stillman,Randy Strich,Kevin Struhl,Jasper Q. Svejstrup,Simon Tuck,Fred Winston,Robert G. Roeder,Roger D. Kornberg +47 more
TL;DR: A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II is proposed.
Journal ArticleDOI
Defining the sequence-recognition profile of DNA-binding molecules.
Christopher L. Warren,Natasha C. S. Kratochvil,Karl E. Hauschild,Shane Foister,Mary L. Brezinski,Peter B. Dervan,George N. Phillips,Aseem Z. Ansari +7 more
TL;DR: A high-throughput approach that provides a comprehensive profile of the binding properties of DNA-binding molecules, based on displaying every permutation of a duplex DNA sequence on a microfabricated array, has determined the full molecular recognition profile of an engineered small molecule and a eukaryotic transcription factor.