Cathelijne W. van den Berg

TL;DR: It is demonstrated that both embryonic stem cell- and iPSC-derived cardiomyocytes can recapitulate the characteristics of a combined gain- and loss-of-function Na+ channel mutation and that the electrophysiological immaturity of PSC-derived CARDIomyocytes does not preclude their use as an accurate model for cardiac Na+Channel disease.

TL;DR: It is shown that hPSC-derived kidney organoids, derived in fully defined medium conditions and in the absence of any exogenous vascular endothelial growth factor, develop host-derived vascularization, demonstrating that functional vascularization is required for progressive morphogenesis of human kidney organs.

TL;DR: The analysis of gene expression in the human foetal heart reveals stage- and chamber-specific genes and provides a dataset that can be used for benchmarking human PSC-derived heart cells.

TL;DR: Some of the genetic diseases that affect the heart are discussed and how new paradigms in vitro could assist the understanding of cardiac pathogenesis and aid in drug discovery are illustrated.

TL;DR: A directed differentiation monolayer protocol is developed that can be used to generate cultures comprising ~50% cardiomyocytes, in which both the culture of the undifferentiated human pluripotent stem cells (hPSCs) and the differentiation procedure itself are defined and serum-free.