Catherine Fagundez

TL;DR: The results from the synthesis of peptides by Fmoc/SPPS on a 2-CTC resin and then lactamization in solution or solid phase for the preparation of cyclopeptides are presented and the activities of the corresponding cyclopesptides against the chloroquine-resistant K1 strain of Plasmodium falciparum were evaluated.

TL;DR: Cyclopeptides containing N-methyl amino acids with in vitro activity against erythrocytic forms as well as liver stage with in vivo evaluation, and mice pharmacokinetics are presented.

TL;DR: Cyclohexapeptide analogs of natural products were obtained in very good yields by a combination of solid-phase peptide synthesis, for the linear peptide, and solution cyclization, and preliminary structure–activity relationships are presented.

TL;DR: A versatile palladium-catalyzed tandem synthetic sequence to afford E-stilbenes libraries has been developed by means of the sequence of Hiyama and Heck cross-couplings.

TL;DR: In this article, an optimized process was described to obtain voacangine from V. africana root bark as a precursor of the iboga scaffold, using a direct acetone-based extraction procedure (0.5 kg of root bark).