G
Gustavo Seoane
Researcher at University of the Republic
Publications - 125
Citations - 2144
Gustavo Seoane is an academic researcher from University of the Republic. The author has contributed to research in topics: Toluene dioxygenase & Total synthesis. The author has an hindex of 22, co-authored 120 publications receiving 1932 citations. Previous affiliations of Gustavo Seoane include University of Chile & Virginia Tech.
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Journal ArticleDOI
Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships.
Mauricio Cabrera,Macarena Simoens,Gabriela Falchi,M. Laura Lavaggi,Oscar E. Piro,Eduardo E. Castellano,Anabel Vidal,Amaia Azqueta,Antonio Monge,Adela López de Cerain,Gabriel Sagrera,Gustavo Seoane,Hugo Cerecetto,Mercedes González +13 more
TL;DR: A series of synthetic chalcones, flavanones, and flavones has been synthesized and evaluated for antitumor activity against the human kidney carcinoma cells TK-10, human mammary adenocarcinoma cells MCF-7 (estrogen receptor-positive), and human colon adenOCarcinomas cells HT-29.
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C−C Bond-Forming Lyases in Organic Synthesis
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1,2,5-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: structure-activity relationships.
Hugo Cerecetto,R. Di Maio,Mercedes González,M. Risso,P. Saenz,Gustavo Seoane,Ana Denicola,Gonzalo Peluffo,C. Quijano,Claudio Olea-Azar +9 more
TL;DR: Electrochemical studies and ESR spectroscopy show that the highest activities observed are associated with the facile monoelectronation of the N-oxide moiety, and Lipophilic-hydrophilic balance of the compounds could also play an important role in their effectiveness as antichagasic drugs.
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Synthesis and antitrypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives. structure-activity relationships.
Hugo Cerecetto,R. Di Maio,Mercedes González,Mariela Risso,Gabriel Sagrera,Gustavo Seoane,Ana Denicola,Gonzalo Peluffo,Celia Quijano,Andrés O.M. Stoppani,Margot Paulino,Claudio Olea-Azar,Miguel A. Basombrío +12 more
TL;DR: A correlation was found between lipophilic-hydrophilic properties and trypanocidal activity, high R(M) values being associated with low in vivo effects, and two compounds displayed the highest in vivo activity.
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Topological selectivity in the intramolecular [4 + 1] pyrroline annulation. Formal total stereospecific synthesis of (.+-.)-supinidine, (.+-.)-isoretronecanol, and (.+-.)-trachelanthamidine
Tomas Hudlicky,James O. Frazier,Gustavo Seoane,Mark. Tiedje,Ana. Seoane,Lawrence D. Kwart,Chris. Beal +6 more