Lindsay B. Stewart

TL;DR: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin "gold standard", artesunate and it displays low lipophilicity and negligible neuro- and cytotoxicity in in vitro and in vivo assays.

TL;DR: Against an overall background of negatively skewed frequencies, as expected from historical population expansion combined with purifying selection, the outlying minority of genes with signatures indicating exceptionally intermediate frequencies were identified; such signatures were most common in those with peak expression at the merozoite stage that invades erythrocytes.

TL;DR: The mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries are analysed and it is found that they are non-recombining and co-inherited.

TL;DR: 15 manually curated new reference genome sequences with their nearly complete subtelomeric regions and fully assembled genes are an important new resource for the malaria research community and report the overall conserved structure and pattern of important gene families and the more clearly defined subtelomersic regions.

TL;DR: An imidazopyridine series is generated that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to mosquitoes and warrants consideration for further development to produce an antimalarial drug.