Z
Zachary Gerhart-Hines
Researcher at University of Copenhagen
Publications - 53
Citations - 7910
Zachary Gerhart-Hines is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Thermogenesis & Adipose tissue. The author has an hindex of 21, co-authored 35 publications receiving 6640 citations. Previous affiliations of Zachary Gerhart-Hines include University of Pennsylvania & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity
Carles Cantó,Zachary Gerhart-Hines,Jerome N. Feige,Marie Lagouge,Liliana Noriega,Liliana Noriega,Jill C. Milne,Peter J. Elliott,Pere Puigserver,Johan Auwerx,Johan Auwerx +10 more
TL;DR: It is demonstrated that AMPK controls the expression of genes involved in energy metabolism in mouse skeletal muscle by acting in coordination with another metabolic sensor, the NAD+-dependent type III deacetylase SIRT1.
Journal ArticleDOI
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
Zachary Gerhart-Hines,Zachary Gerhart-Hines,Joseph T. Rodgers,Joseph T. Rodgers,Olivia Bare,Carles Lerin,Carles Lerin,Seung hee Kim,Seung hee Kim,Raul Mostoslavsky,Frederick W. Alt,Zhidan Wu,Pere Puigserver,Pere Puigserver +13 more
TL;DR: SIRT1 is identified as a functional regulator of PGC‐1α that induces a metabolic gene transcription program of mitochondrial fatty acid oxidation in response to low glucose concentrations and has implications for understanding selective nutrient adaptation and how it might impact lifespan or metabolic diseases such as obesity and diabetes.
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Antioxidant and Oncogene Rescue of Metabolic Defects Caused by Loss of Matrix Attachment
Zachary T. Schafer,Alexandra R. Grassian,Loling Song,Zhenyang Jiang,Zachary Gerhart-Hines,Zachary Gerhart-Hines,Hanna Y. Irie,Sizhen Gao,Pere Puigserver,Joan S. Brugge +9 more
TL;DR: The results show both the importance of matrix attachment in regulating metabolic activity and an unanticipated mechanism for cell survival in altered matrix environments by antioxidant restoration of ATP generation by antioxidant treatment.
Journal ArticleDOI
Metabolic adaptations through the PGC-1α and SIRT1 pathways
TL;DR: Understanding the PGC‐1α and SIRT1 pathways might have important implications for comprehending metabolic and age‐associated diseases.
Journal ArticleDOI
The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD +
Zachary Gerhart-Hines,Zachary Gerhart-Hines,John E. Dominy,Sharon M. Blättler,Mark P. Jedrychowski,Alexander S. Banks,Ji Hong Lim,Helen Chim,Steven P. Gygi,Pere Puigserver +9 more
TL;DR: A cAMP-induced phosphorylation of a highly conserved serine (S434) located in the SIRT1 catalytic domain that rapidly enhanced intrinsic deacetylase activity independently of changes in NAD(+) levels is identified.