C
Cécile Martinat
Researcher at French Institute of Health and Medical Research
Publications - 64
Citations - 3353
Cécile Martinat is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 20, co-authored 48 publications receiving 2939 citations. Previous affiliations of Cécile Martinat include Centre national de la recherche scientifique & Université Paris-Saclay.
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Journal ArticleDOI
DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation
TL;DR: It is demonstrated that DJ-1 functions as a redox-sensitive molecular chaperone that is activated in an oxidative cytoplasmic environment and extends to α-synuclein, a protein implicated in PD pathogenesis.
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Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity
John F. Staropoli,Caroline McDermott,Cécile Martinat,Brenda A. Schulman,Elena Y. Demireva,Asa Abeliovich +5 more
TL;DR: Parkin deficiency potentiates the accumulation of cyclin E in cultured postmitotic neurons exposed to the glutamatergic excitotoxin kainate and promotes their apoptosis, and parkin overexpression attenuates the accumulation in toxin-treated primary neurons, including midbrain dopamine neurons, and protects them from apoptosis.
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Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.
Cécile Martinat,Shoshana Shendelman,Alan Jonason,Thomas Leete,M. Flint Beal,Lichuan Yang,Thomas Floss,Asa Abeliovich +7 more
TL;DR: It is found that dopamine neurons derived from in vitro–differentiated DJ-1-deficient embryonic stem cells display decreased survival and increased sensitivity to oxidative stress, and the utility of genetically modified embryonic stem cell–derived neurons as cellular models of neuronal disorders is demonstrated.
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Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes
Yves Maury,Julien Côme,Rebecca A. Piskorowski,Nouzha Salah-Mohellibi,Vivien Chevaleyre,Marc Peschanski,Cécile Martinat,Stéphane Nedelec +7 more
TL;DR: An unappreciated role for canonical Wnt signaling is revealed in specifying motor neuron diversity from hPSCs and a systematic approach to improving hPSC-targeted differentiation is described, which should facilitate disease modeling studies and drug screening assays.
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Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype
Cécile Martinat,Jean-Jacques Bacci,Thomas Leete,Jongpil Kim,William B. Vanti,Amy Hauck Newman,Joo Hwan Cha,Ulrik Gether,Honggang Wang,Asa Abeliovich +9 more
TL;DR: It is shown that Nurr1 and Pitx3 cooperatively promote terminal maturation to the midbrain DA neuron phenotype in murine and human ES cell cultures.