C
Cecilia S. L. Lai
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 8
Citations - 4481
Cecilia S. L. Lai is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: FOXP2 & Language disorder. The author has an hindex of 7, co-authored 8 publications receiving 4277 citations. Previous affiliations of Cecilia S. L. Lai include University College London.
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Journal ArticleDOI
A forkhead-domain gene is mutated in a severe speech and language disorder
TL;DR: It is suggested that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is involved in the developmental process that culminates in speech and language.
Journal ArticleDOI
Molecular evolution of FOXP2, a gene involved in speech and language
Wolfgang Enard,Molly Przeworski,Simon E. Fisher,Cecilia S. L. Lai,Victor Wiebe,Takashi Kitano,Anthony P. Monaco,Svante Pääbo +7 more
TL;DR: It is shown that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution.
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Identification of FOXP2 Truncation as a Novel Cause of Developmental Speech and Language Deficits
Kay D. MacDermot,Elena Bonora,Nuala Sykes,Anne Marie Coupe,Cecilia S. L. Lai,Sonja C. Vernes,Faraneh Vargha-Khadem,Fiona Haslam McKenzie,Robert L. Smith,Anthony P. Monaco,Simon E. Fisher +10 more
TL;DR: Investigation of the entire coding region of FOXP2, including alternatively spliced exons, in 49 probands affected with verbal dyspraxia and the discovery of the first nonsense mutation in FoxP2 opens the door for detailed investigations of neurodevelopment in people carrying different etiological variants of the gene.
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FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder.
TL;DR: The homologous pattern of FOXP2/Foxp2 expression in human and mouse argues for a role for this gene in development of motor-related circuits throughout mammalian species.
Journal ArticleDOI
FOXP2 is not a major susceptibility gene for autism or specific language impairment.
Dianne F. Newbury,Enzo Bonora,Janine A. Lamb,Simon E. Fisher,Cecilia S. L. Lai,Gillian Baird,L. Jannoun,Vicky Slonims,Carol Stott,M. J. Merricks,Patrick Bolton,Anthony J. Bailey,Anthony P. Monaco +12 more
TL;DR: It is concluded that coding-region variants in FOXP2 do not underlie the AUTS1 linkage and that the gene is unlikely to play a role in autism or more common forms of language impairment.