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Célia Regina Cavichiolo Franco
Researcher at Federal University of Paraná
Publications - 62
Citations - 1112
Célia Regina Cavichiolo Franco is an academic researcher from Federal University of Paraná. The author has contributed to research in topics: Fibronectin & Endothelial stem cell. The author has an hindex of 17, co-authored 58 publications receiving 907 citations.
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Journal ArticleDOI
Structural and hemostatic activities of a sulfated galactofucan from the brown alga Spatoglossum schroederi. An ideal antithrombotic agent
Hugo Alexandre Oliveira Rocha,Fabio A. Moraes,Edvaldo S. Trindade,Célia Regina Cavichiolo Franco,Ricardo J.S. Torquato,Silvio Sanches Veiga,Ana P. Valente,Paulo A.S. Mourão,Edda Lisboa Leite,Helena B. Nader,Carl P. Dietrich +10 more
TL;DR: The brown alga Spatoglossum schroederi contains three fractions of sulfated polysaccharides as mentioned in this paper, which contain fucose, xylose, galactose, and sulfate in a molar ratio 1.0:0.5:2.
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Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom.
Rafael Bertoni da Silveira,Rafael Bertoni da Silveira,Ana Carolina Martins Wille,Ana Carolina Martins Wille,Olga Meiri Chaim,Olga Meiri Chaim,Marcia Helena Appel,Dilza Trevisan Silva,Célia Regina Cavichiolo Franco,Leny Toma,Oldemir C. Mangili,Waldemiro Gremski,Waldemiro Gremski,Carl P. Dietrich,Helena B. Nader,Silvio Sanches Veiga +15 more
TL;DR: Sequence comparison, phylogenetic analysis and analysis of the functional recombinant toxin revealed that LALP is related in both structure and function to the astacin family of metalloproteases, suggesting that an astacIn-like toxin is present in a animal venom secretion and indicates that recombinant LALp will be a useful tool for future structural and functional studies on venom and the astACin family.
Journal ArticleDOI
Experimental Evidence for a Direct Cytotoxicity of Loxosceles intermedia (Brown Spider) Venom in Renal Tissue
Melissa N. Luciano,Paulo Henrique da Silva,Olga Meiri Chaim,Vera Lucia Pereira dos Santos,Célia Regina Cavichiolo Franco,Maria Fernanda Soares,Silvio M. Zanata,Oldemir C. Mangili,Waldemiro Gremski,Silvio Sanches Veiga +9 more
TL;DR: Experimental evidence is provided that L. intermedia venom is directly involved in nephrotoxicity and caused azotemia with elevation of blood urea levels but did not decrease C3 complement concentration or cause hemolysis in vivo.
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Mechanisms operated by endothelin ETA and ETB receptors in the trigeminal ganglion contribute to orofacial thermal hyperalgesia induced by infraorbital nerve constriction in rats.
Juliana Geremias Chichorro,Aleksander Roberto Zampronio,Daniela Almeida Cabrini,Célia Regina Cavichiolo Franco,Giles A. Rae +4 more
TL;DR: In this article, the authors investigated which cell types express endothelin receptors in the trigeminal ganglion, and the contribution of mechanisms mediated by ET A and ET B receptors to orofacial heat hyperalgesia induced by unilateral constriction of the infraorbital nerve (CION).
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A Non-Anticoagulant Heterofucan has Antithrombotic Activity in vivo
Edjane M A Barroso,Leandro Silva Costa,Valquíria P. Medeiros,Sara Lima Cordeiro,Mariana Santana Santos Pereira Costa,Célia Regina Cavichiolo Franco,Helena B. Nader,Edda Lisboa Leite,Hugo Alexandre Oliveira Rocha +8 more
TL;DR: The hypothesis has been raised that the in vivo antithrombotic activity of fucan A is related to the increased production of this heparan from endothelial cells like heparin, and the data suggest that it may be an ideal antithromabotic agent in vivo.