G
Giles A. Rae
Researcher at Universidade Federal de Santa Catarina
Publications - 114
Citations - 3096
Giles A. Rae is an academic researcher from Universidade Federal de Santa Catarina. The author has contributed to research in topics: Endothelin receptor & Endothelins. The author has an hindex of 33, co-authored 113 publications receiving 2951 citations.
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Journal ArticleDOI
Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice
Raquel M. Teixeira,Adair R.S. Santos,Sandro J. Ribeiro,João B. Calixto,Giles A. Rae,Thereza Christina Monteiro de Lima +5 more
TL;DR: The results suggest that centrally administered NK1 and NK2 receptor agonists and antagonists can modulate anxiety, as evaluated in the elevated plus-maze test in mice.
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Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test.
Elaine C. Gavioli,Giuliano Marzola,Remo Guerrini,Rosalia Bertorelli,Silvia Zucchini,T.C.M. De Lima,Giles A. Rae,S. Salvadori,Domenico Regoli,Girolamo Calo +9 more
TL;DR: Results indicate that blockade of the N/OFQ‐NOP receptor signalling in the brain produces antidepressant‐like effects in the mouse FST, and support the NOP receptor as a candidate target for the development of innovative antidepressant drugs.
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Endothelin‐1‐induced ETA receptor‐mediated nociception, hyperalgesia and oedema in the mouse hind‐paw: modulation by simultaneous ETB receptor activation
TL;DR: Endothelin‐1 triggers ETA receptor‐mediated nociception, hyperalgesia and oedema in the mouse hind‐paw, and simultaneous activation of ETB receptors by endothelins‐1 or selective agonists can limit thehyperalgesic, but not the nocICEptive or oedematogenic, effects of the peptide.
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Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice
Elaine C. Gavioli,Elaine C. Gavioli,Christopher W. Vaughan,Giuliano Marzola,Remo Guerrini,Vanessa A. Mitchell,Silvia Zucchini,T.C.M. De Lima,Giles A. Rae,S. Salvadori,Domenico Regoli,Girolamo Calo +11 more
TL;DR: UFP-101 exhibits pronounced antidepressant-like effects in different species and animal models, possibly by preventing the inhibitory effects of endogenous N/OFQ on brain monoaminergic (in particular serotonergic) neurotransmission.
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Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection
Alessandra C. Martini,Alessandra C. Martini,Alessandra C. Martini,Temugin Berta,Temugin Berta,Stefânia Forner,Stefânia Forner,Gang Chen,Allisson Freire Bento,Ru-Rong Ji,Giles A. Rae +10 more
TL;DR: The dual anti-inflammatory and analgesic properties of LXA4, allied to its endogenous nature and safety profile, may render this lipid mediator as new therapeutic approach for treating various neuroinflammatory disorders and chronic pain with only limited side effects.