Structural and hemostatic activities of a sulfated galactofucan from the brown alga Spatoglossum schroederi. An ideal antithrombotic agent
Hugo Alexandre Oliveira Rocha,Fabio A. Moraes,Edvaldo S. Trindade,Célia Regina Cavichiolo Franco,Ricardo J.S. Torquato,Silvio Sanches Veiga,Ana P. Valente,Paulo A.S. Mourão,Edda Lisboa Leite,Helena B. Nader,Carl P. Dietrich +10 more
TLDR
The brown alga Spatoglossum schroederi contains three fractions of sulfated polysaccharides as mentioned in this paper, which contain fucose, xylose, galactose, and sulfate in a molar ratio 1.0:0.5:2.About:
This article is published in Journal of Biological Chemistry.The article was published on 2005-12-16 and is currently open access. It has received 138 citations till now. The article focuses on the topics: Heparan sulfate.read more
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Fucoidan: Structure and Bioactivity
TL;DR: This review summarizes the research progress on the structure and bioactivity of fucoidan and the relationships between structure andBioactivity and several fucoidans’ structures have been solved.
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Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae
TL;DR: The present paper will provide an update on the structural chemistry of the major sulfated polysaccharides synthesized by seaweeds including the galactans, ulvans, and fucans and the recent findings on the anticoagulant/antithrombotic, antiviral, immuno-inflammatory, antilipidemic and antioxidant activities of sulfated Polysaccharide and their potential for therapeutic application.
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Important determinants for fucoidan bioactivity: a critical review of structure-function relations and extraction methods for fucose-containing sulfated polysaccharides from brown seaweeds.
TL;DR: The aim of this review is to provide information on the most recent developments in the chemistry of fucoidan/FCSPs emphasizing the significance of different extraction techniques for the structural composition and biological activity with particular focus on sulfate groups.
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Marine pharmacology in 2005–6: Marine Compounds with Anthelmintic, Antibacterial, Anticoagulant, Antifungal, Anti-inflammatory, Antimalarial, Antiprotozoal, Antituberculosis, and Antiviral Activities; affecting the Cardiovascular, Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action
TL;DR: Marine pharmacology research during 2005-2006 was truly global in nature, involving investigators from 32 countries, and the United States, and contributed 183 marine chemical leads to the research pipeline aimed at the discovery of novel therapeutic agents.
Journal ArticleDOI
Antioxidant activities of sulfated polysaccharides from brown and red seaweeds
Micheline Cristiane Rocha de Souza,Cybelle Teixeira Marques,Celina Maria P. Guerra Dore,Fernando Roberto Ferreira Silva,Hugo Alexandre Oliveira Rocha,Edda Lisboa Leite +5 more
TL;DR: The results clearly indicate the beneficial effect of algal polysaccharides as antioxidants in the food industry, as iota, kappa and lambda carrageenans had an inhibitory effect on the formation of hydroxyl radicals and fucan fractions showed low antioxidant activity relative to fucoidan.
References
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Colorimetric Method for Determination of Sugars and Related Substances
TL;DR: In this article, a method was developed to determine submicro amounts of sugars and related substances using a phenol-sulfuric acid reaction, which is useful for the determination of the composition of polysaccharides and their methyl derivatives.
Journal ArticleDOI
Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein.
TL;DR: The Coomassie brilliant blue G assay for proteins described by Bradford (1976) (Anal Biochem72, 248) was reexamined and it was found that the extinction coefficient of the dye-protein complex solution remained constant over the protein concentration range of 08 to 10 μg/ml of solution.
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Sulfated fucans, fresh perspectives : structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide
Olivier Berteau,Barbara Mulloy +1 more
TL;DR: The availability of purified fucans and fucan fractions with simple, but varied structures, in conjunction with the development of new enzymatic tools, demonstrate that the biological properties of sulfation are not only a simple function of their charge density but also are determined by detailed structural features.
Journal ArticleDOI
A revised structure for fucoidan may explain some of its biological activities
TL;DR: The revised average structure for fucoidan is consistent with previous studies suggesting a branched random coil as the best model for this polysaccharide and the proposed model is a closer structural analogue of the sulfated carbohydrate ligands that bind to selectins.
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Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies
TL;DR: Fractionation with the cationic detergent cetrimide has allowed achieving a better separation of the galactofucan and uronofucoidan components, which show a high inhibitory activity against herpes simplex virus 1 and 2, with no cytotoxicity.
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Albana Cumashi,N. A. Ushakova,M. E. Preobrazhenskaya,Armida D'Incecco,Antonio Piccoli,Licia Totani,Nicola Tinari,Galina E. Morozevich,A. E. Berman,Maria I. Bilan,Anatolii I. Usov,Nadezhda E. Ustyuzhanina,Alexey A. Grachev,Craig J. Sanderson,Maeve Kelly,Gabriel A. Rabinovich,Stefano Iacobelli,Nikolay E. Nifantiev +17 more