Céline Feillet

TL;DR: It is shown that in unsynchronized cells the cell cycle and circadian clock robustly phase lock each other in a 1:1 fashion so that in an expanding cell population the two oscillators oscillate in a synchronized way with a common frequency.

TL;DR: It is proposed that the cell cycle may be synchronized or slowed down through coupling with the circadian clock, which results in reduced tumor growth in both healthy and cancerous cells.

TL;DR: This study aims at helping biologists to elicit the impact of growth factor concentration on cell cycle regulation, at making more precise the dynamics of key mechanisms controlling the division cycle in proliferating cell populations, and eventually at establishing theoretical bases for optimised combined anticancer treatments.

TL;DR: It is shown that the non-circadian nuclear receptor and metabolic sensor Liver X Receptor alpha (LXRα) which is known to regulate glucocorticoid production in mice modulates the sex specific circadian pattern of plasma corticosterone, indicating that LXRα is a determinant of sexually dimorphic circadian patterns of key physiological parameters.

TL;DR: It is shown that hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbα-Chkα axis and suggested that an intact circadian timing system is important for the temporal coordination of phospholipid metabolism.