F
Franck Delaunay
Researcher at French Institute of Health and Medical Research
Publications - 76
Citations - 5306
Franck Delaunay is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 31, co-authored 73 publications receiving 4893 citations. Previous affiliations of Franck Delaunay include Centre national de la recherche scientifique & École Normale Supérieure.
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Journal ArticleDOI
Effects of Chronic Jet Lag on Tumor Progression in Mice
Elisabeth Filipski,Franck Delaunay,Verdun M. King,Ming-Wei Wu,Bruno Claustrat,Aline Gréchez-Cassiau,Catherine Guettier,Michael H. Hastings,Lévi Francis +8 more
TL;DR: Altered environmental conditions can disrupt circadian clock molecular coordination in peripheral organs including tumors and play a significant role in malignant progression.
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Estrogen receptor β acts as a dominant regulator of estrogen signaling
TL;DR: It is shown that co-localization and subsequent heterodimerization of ERα and ERβ may result in receptor activity distinct from that of ER homodimers, and that ERβ can act as a negative or positive dominant regulator of ER activity.
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Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids.
Franck Delaunay,Akhtar Khan,Antonio Cintra,Behrous Davani,Zong Chao Ling,Arne Andersson,Claes-Göran Östenson,Jan-Ake Gustafsson,Suad Efendic,Sam Okret +9 more
TL;DR: Results show that glucocorticoids directly inhibit insulin release in vivo and identify the pancreatic beta cell as an important target for the diabetogenic action of glucoc Corticoids.
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Reciprocal Regulation of Brain and Muscle Arnt-Like Protein 1 and Peroxisome Proliferator-Activated Receptor α Defines a Novel Positive Feedback Loop in the Rodent Liver Circadian Clock
Laurence Canaple,Juliette Rambaud,Ouria Dkhissi-Benyahya,Béatrice Rayet,Nguan Soon Tan,Liliane Michalik,Franck Delaunay,Walter Wahli,Vincent Laudet +8 more
TL;DR: It is demonstrated that PPARalpha plays a specific role in the peripheral circadian control because it is required to maintain the circadian rhythm of the master clock gene brain and muscle Arnt-like protein 1 (bmal1) in vivo and fenofibrate induces calendar rhythm of clock gene expression in cell culture and up-regulates hepatic bmal1 in vivo.
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Ligand binding and nuclear receptor evolution.
TL;DR: Arguments from phylogenetic, functional and structural studies are presented that support the hypothesis that there have been several independent gains of ligand‐binding ability of nuclear receptors during metazoan evolution.