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Cesaria Prontera
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 8
Citations - 647
Cesaria Prontera is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Matrix metalloproteinase & Gene expression. The author has an hindex of 7, co-authored 8 publications receiving 633 citations.
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Journal ArticleDOI
Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability.
Francesco Cipollone,Cesaria Prontera,Barbara Pini,Matteo Marini,Maria Fazia,Domenico De Cesare,Annalisa Iezzi,Sante Ucchino,Gianfranco Boccoli,Vittorio Saba,Francesco Chiarelli,Franco Cuccurullo,Andrea Mezzetti +12 more
TL;DR: This study provides evidence that synthesis of COX-2 and PGES by activated macrophages is associated with acute ischemic syndromes, possibly through metalloproteinase-induced plaque rupture.
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Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma.
TL;DR: The hypothesis of an essential role of metalloproteinase(s) in the metastatic process is supported and blockade of invasion, angiogenesis and other processes mediated by metalliproteinases may underlie the anti‐tumor and anti‐metastatic effect of BB‐94 and captopril and their combination.
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Balance Between PGD Synthase and PGE Synthase Is a Major Determinant of Atherosclerotic Plaque Instability in Humans
Francesco Cipollone,Maria Fazia,Annalisa Iezzi,Giovanni Ciabattoni,Barbara Pini,Chiara Cuccurullo,Sante Ucchino,Francesco Spigonardo,Mariella De Luca,Cesaria Prontera,Francesco Chiarelli,Franco Cuccurullo,Andrea Mezzetti +12 more
TL;DR: Results suggest that COX-2 may have proinflammatory and antiinflammatory properties as a function of expression of downstream PGH2 isomerases, and that the switch from L-PGDS to mPGES-1 in plaque macrophages is associated with cerebral ischemic syndromes, possibly through MMP-induced plaque rupture.
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O6-methylguanine inhibits the binding of transcription factors to DNA
TL;DR: In this article, the effect of methylation of O6-guanine on the binding of cellular factors to different DNA sequences, modified oligonucleotides were constructed, in which o6-MethylGuanine (O6-MeG) replaced some guanines.
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Inhibition by interleukin-4 of stromelysin expression in human skin fibroblasts : role of pkc
TL;DR: In human dermal fibroblasts, activation of PKC abolishes the observed IL-4 effect on both basal and IL-1 beta-induced stromelysin gene expression, and it appears that lack ofPKC activation is a prerequisite for the inhibitory effect ofIL-4 in the system.