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Chae-Myeong Ha
Researcher at University of Alabama at Birmingham
Publications - 24
Citations - 1228
Chae-Myeong Ha is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Mitochondrion & Vascular smooth muscle. The author has an hindex of 15, co-authored 22 publications receiving 805 citations. Previous affiliations of Chae-Myeong Ha include Kyungpook National University & Kyungpook National University Hospital.
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Journal ArticleDOI
Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes
Luong Dai Ly,Shanhua Xu,Seong Kyung Choi,Chae-Myeong Ha,Themis Thoudam,Seung Kuy Cha,Andreas Wiederkehr,Claes B. Wollheim,Inkyu Lee,Kyu Sang Park +9 more
TL;DR: A vicious cycle of lipotoxicity occurs in multiple tissues, resulting in β-cell failure and insulin resistance in target tissues, and further aggravates diabetic complications.
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Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
Sungmi Park,Jae-Han Jeon,Byong Keol Min,Chae-Myeong Ha,Themis Thoudam,Bo Yoon Park,Inkyu Lee,Inkyu Lee +7 more
TL;DR: The roles of PDC in diverse tissues and how regulation of its activity is affected in various metabolic disorders are summarized.
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PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
Themis Thoudam,Chae-Myeong Ha,Jaechan Leem,Dipanjan Chanda,Jong-Seok Park,Hyo Jeong Kim,Jae-Han Jeon,Yeon Kyung Choi,Suthat Liangpunsakul,Yang Hoon Huh,Tae-Hwan Kwon,Keun-Gyu Park,Robert A. Harris,Kyu Sang Park,Hyun-Woo Rhee,Inkyu Lee +15 more
TL;DR: It is demonstrated that PDK4 interacts with and stabilizes the IP3R1-GRP75-VDAC1 complex at the MAM interface and that forced formation and stabilization of MAMs with synthetic ER–mitochondria linker prevented the beneficial effects ofPDK4 deficiency on insulin signaling.
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α‐Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway
Hyun-Soo Kim,Han-Jong Kim,Kyung-Hee Lee,Jin Man Kim,Hee Sun Kim,Jae-Ryong Kim,Chae-Myeong Ha,Choi Young Keun,Sun Joo Lee,Joon-Young Kim,Robert A. Harris,Robert A. Harris,Daewon Jeong,Inkyu Lee +13 more
TL;DR: In this paper, the effect of α-lipoic acid (ALA), a naturally occurring antioxidant that improves mitochondrial function, on vascular calcification in vitro and in vivo was investigated.
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Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
Chang Joo Oh,Chae-Myeong Ha,Young-Keun Choi,Sungmi Park,Mi Sun Choe,Nam Ho Jeoung,Yang Hoon Huh,Hyo Jeong Kim,Hee Seok Kweon,Ji Min Lee,Sun Joo Lee,Jae-Han Jeon,Robert A. Harris,Keun-Gyu Park,Inkyu Lee +14 more
TL;DR: PDK4 mediates cisplatin-induced acute kidney injury, suggesting that PDK4 might be a therapeutic target for attenuating cisPlatin- induced acute kidneys injury.