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Chandrima Das
Researcher at Saha Institute of Nuclear Physics
Publications - 82
Citations - 2851
Chandrima Das is an academic researcher from Saha Institute of Nuclear Physics. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 20, co-authored 67 publications receiving 2447 citations. Previous affiliations of Chandrima Das include Indian Council of Medical Research & Bhabha Atomic Research Centre.
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CBP/p300-mediated acetylation of histone H3 on lysine 56.
TL;DR: It is shown that, in response to DNA damage, histones bearing acetylated K56 are assembled into chromatin in Drosophila and human cells, forming foci that colocalize with sites of DNA repair.
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CBP/p300-mediated acetylation of histone H3 on lysine 56 (Nature (2009) 459, (113-117))
TL;DR: This corrects the article to show that the Higgs boson bacterium is a prokaryotic substance, not a “spatially aggregating substance” as previously reported, which can be a source of disease in animals.
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Elevated Histone Expression Promotes Life Span Extension
Jason Feser,David M. Truong,Chandrima Das,Joshua J. Carson,Jeffrey S. Kieft,Jeffrey S. Kieft,Troy A. A. Harkness,Jessica K. Tyler,Jessica K. Tyler +8 more
TL;DR: It is indicated that maintenance of the fundamental chromatin structure is critical for slowing down the aging process and reveals that increasing the histone supply extends life span.
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The histone shuffle: histone chaperones in an energetic dance
TL;DR: Structural, biophysical and biochemical studies have begun to shed light on the molecular mechanisms whereby histone chaperones promote chromatin assembly, disassembly and histone exchange to facilitate DNA replication, repair and transcription.
Journal ArticleDOI
Histone exchange and histone modifications during transcription and aging.
Chandrima Das,Jessica K. Tyler +1 more
TL;DR: The current mechanistic understanding of this process and the evidence for profound changes in chromatin dynamics during aging are presented.