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Jessica K. Tyler

Researcher at Cornell University

Publications -  106
Citations -  10351

Jessica K. Tyler is an academic researcher from Cornell University. The author has contributed to research in topics: Chromatin & Histone code. The author has an hindex of 42, co-authored 100 publications receiving 8588 citations. Previous affiliations of Jessica K. Tyler include University of Texas MD Anderson Cancer Center & University of California, San Diego.

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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CBP/p300-mediated acetylation of histone H3 on lysine 56.

TL;DR: It is shown that, in response to DNA damage, histones bearing acetylated K56 are assembled into chromatin in Drosophila and human cells, forming foci that colocalize with sites of DNA repair.
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Epigenetics and aging.

TL;DR: Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process, and inhibitors of epigenetic enzymes can influence life span of model organisms.
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The RCAF complex mediates chromatin assembly during DNA replication and repair

TL;DR: Genetic analyses in Saccharomyces cerevisiae demonstrate that ASF1 is essential for normal cell cycle progression, and suggest that RCAF mediates chromatin assembly after DNA replication and the repair of double-strand DNA damage in vivo.
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Structural Basis for the Histone Chaperone Activity of Asf1

TL;DR: The Asf1-H3/H4 structure suggests a "strand-capture" mechanism whereby the H4 tail acts as a lever to facilitate chromatin disassembly/assembly that may be used ubiquitously by histone chaperones.