C
Chang Yu
Researcher at Vanderbilt University Medical Center
Publications - 128
Citations - 4071
Chang Yu is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Population & Internal medicine. The author has an hindex of 33, co-authored 118 publications receiving 3339 citations. Previous affiliations of Chang Yu include Vanderbilt University & Yale University.
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Journal ArticleDOI
Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: A double-blind trial ☆
TL;DR: Addition of a cyclooxygenase-2 (COX-2) selective inhibitor to low-dose aspirin increased ulcer incidence, to a rate not significantly less than a nonselective nonsteroidal anti-inflammatory drug (NSAID) alone.
Journal ArticleDOI
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.
Anna R. Hemnes,Anandharajan Rathinasabapathy,Eric A. Austin,Evan L. Brittain,Erica J. Carrier,Xinping Chen,Joshua P. Fessel,Candice D. Fike,Peter Fong,Niki L Fortune,Robert E. Gerszten,Jennifer Johnson,Mark R. Kaplowitz,John H. Newman,Robert N. Piana,Meredith E. Pugh,Todd W. Rice,Ivan M. Robbins,Lisa Wheeler,Chang Yu,James E. Loyd,James West +21 more
TL;DR: Augmentation of ACE2 in a pilot study was well tolerated, associated with improved pulmonary haemodynamics and reduced markers of oxidant and inflammatory mediators and Targeting this pathway may be beneficial in human PAH.
Journal ArticleDOI
Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease
Jorge L. Gamboa,Frederic T. Billings,Matthew T. Bojanowski,Laura A. A. Gilliam,Chang Yu,Baback Roshanravan,L. Jackson Roberts,Jonathan Himmelfarb,T. Alp Ikizler,Nancy J. Brown +9 more
TL;DR: Mitochondrial abnormalities, which are common in skeletal muscle from patients with CKD stage 5, may explain the muscle dysfunction associated with frailty and sarcopenia in CKD.
Journal ArticleDOI
The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events.
Richard H. Hunt,Sean E. Harper,Douglas J. Watson,Chang Yu,Hui Quan,Michael Lee,Judith K. Evans,Bettina Oxenius +7 more
TL;DR: The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib is assessed by both endoscopy and analysis of upper gastrointestinal events.
Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor-associated angioedema
James Brian Byrd,Stephanie Harris,James V. Gainer,Chang Yu,Ajai Shreevatsa,Pradeep Putlur,John H. Nadeau,Karine Touzin,Marshall L. Summar,Albert Adam,Nancy J. Brown +10 more
TL;DR: This case-control study tested the hypothesis that dipeptidyl peptidase IV activity and antigen are decreased in sera of patients with a history of angiotensin-converting enzyme inhibitor–associated angioedema, and found that it was true.