H
Hui Quan
Researcher at Merck & Co.
Publications - 75
Citations - 11543
Hui Quan is an academic researcher from Merck & Co.. The author has contributed to research in topics: Rofecoxib & Placebo. The author has an hindex of 33, co-authored 69 publications receiving 11295 citations. Previous affiliations of Hui Quan include United States Military Academy.
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Journal ArticleDOI
Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
Robert S. Bresalier,Robert S. Sandler,Hui Quan,James A. Bolognese,Bettina Oxenius,Kevin J. Horgan,Christopher Lines,Robert H. Riddell,Dion Morton,Angel Lanas,Marvin A. Konstam,John A. Baron +11 more
TL;DR: Among patients with a history of colorectal adenomas, the use of rofecoxib was associated with an increased cardiovascular risk, and cardiovascular mortality was similar in the two groups.
Journal ArticleDOI
Effect of Oral Alendronate on Bone Mineral Density and the Incidence of Fractures in Postmenopausal Osteoporosis
Uri A. Liberman,Stuart R. Weiss,Johann Broll,Helmut W. Minne,Hui Quan,Norman H. Bell,Jose Adolfo Rodriguez-Portales,Robert W. Downs,Jan Dequeker,Murray J. Favus,Ego Seeman,Robert R. Recker,Thomas P. Capizzi,Arthur C. Santora,Antonio Lombardi,Raksha V. Shah,Laurence J. Hirsch,David B. Karpf +17 more
TL;DR: Daily treatment with alendronate progressively increases the bone mass in the spine, hip, and total body and reduces the incidence of vertebral fractures, the progression of vertebra deformities, and height loss in postmenopausal women with osteoporosis.
Journal ArticleDOI
Effect of Oral Alendronate on Bone Mineral Density and the Incidence of Fractures in Postmenopausal Osteoporosis
Uri A. Liberman,Stuart R. Weiss,Johann Broll,Helmut W. Minne,Hui Quan,Norman H. Bell,Jose Adolfo Rodriguez-Portales,Robert W. Downs,Jan Dequeker,Murray J. Favus,Ego Seeman,Robert R. Recker,Thomas P. Capizzi,Arthur C. Santora,Antonio Lombardi,Raksha V. Shah,Laurence J. Hirsch,David B. Karpf +17 more
TL;DR: In this article, the effects of oral alendronate, an aminobisphosphonate, on bone mineral density and the incidence of fractures and height loss in 994 women with postmenopausal osteoporosis were studied.
Journal ArticleDOI
Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs.
M. J. S. Langman,Dennis M. Jensen,Douglas J. Watson,Sean E. Harper,Peng-Liang Zhao,Hui Quan,James A. Bolognese,Thomas J. Simon +7 more
TL;DR: Treatment with rofecoxib was associated with a significantly lower incidence of PUBs than treatment with NSAIDs, based on survival analysis of time to first PUB diagnosis, using Pubs that met pre-specified criteria judged by a blinded, external adjudication committee.
Journal Article
Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids.
Francesca Catella-Lawson,Brendan McAdam,Briggs W. Morrison,Shiv Kapoor,Dean A. Kujubu,Lisa M. Antes,Kenneth C. Lasseter,Hui Quan,Barry J. Gertz,Garret A. FitzGerald +9 more
TL;DR: The data suggest that acute sodium retention by nonsteroidal anti-inflammatory drugs in healthy elderly subjects is mediated by the inhibition of Cox-2, whereas depression of GFR is due to inhibition ofcox-1.