Changquan Calvin Sun

TL;DR: The relationship between tablet friability and tablet mechanical strength follows a power law expression and potential applications of this expedited friability test in facilitating systematic and efficient tablet formulation and tooling design are demonstrated with examples.

TL;DR: The 1:1 cocrystal between piroxicam and saccharin exhibits significantly deteriorated powder compaction properties compared to both coformers as mentioned in this paper, and the molecular origin of this effect is revealed by a systematic investigation of crystal mechanical properties, probed with nanoindentation, and crystal structure analysis.

TL;DR: Overall, tabletability of brittle granules is insensitive to granule size enlargement, which provides a scientific basis to the common practice of incorporating brittle filler to a typical tablet formulation processed by roller compaction granulation.

TL;DR: In this paper, a molecule-centered approach is presented toward crystal habit modification of celecoxib and its effect on oral bioavailability, and two crystal habits of CEL, acicular crystal habit (CEL-A) and a plate-shaped crystal habit(CEL)-P, were obtained by recrystallization from toluene at 25 and 60 °C, respectively.

TL;DR: The profoundly improved tabletability of acetaminophen confirmed the effectiveness of the particle coating approach in improving tableting performance of drugs and is expected to have transformative effects on formulation development of poorly compressible drugs.