Changquan Calvin Sun

TL;DR: Experts from around the globe presented processes, techniques, systems that can be used to evaluate and model in vitro performance of different pharmaceutical dosage forms to explore new approaches to assess in vitroperformance of drug products in December 2019.

TL;DR: In this paper, the authors examined two formulation strategies for mitigating the negative effect of SLS on the dissolution of p-aminobenzoic acid (PABA) by reducing the Q value of its LS salt in the diffusion layer: 1) introducing alkalizing excipient, Na3PO4, to reduce the concentration of PABAH+ by elevating the microenvironment pH, and 2) introducing NaCl to reduce LS- monomer concentration by depressing the critical micelle concentration (CMC).

TL;DR: In this paper, the authors focus on the evolution of granule structures and its connection to properties of granules prepared by high shear wet granulation (HSWG) and discuss the importance of integrated materials science and engineering in solving problems in pharmaceutical product development and manufacturing.

TL;DR: In this article, the authors systematically evaluated the flowability of powders under three preshear normal stresses using a ring shear tester, and the results showed that flowability was positively associated with shear cell size.

TL;DR: Compared to traditional ways to address content uniformity problems, this formulation strategy is much more robust and simpler, making it a potential platform technology for manufacturing tablets of potent APIs.