Changwon Park

TL;DR: Genetically unmodified MSCs can undergo chromosomal abnormalities even at early passages and form malignant tumors when transplanted in vivo, suggesting that careful monitoring of chromosomal status is warranted when in vitro expanded M SCs are used for cell therapy such as for MI.

TL;DR: It is demonstrated that HH is necessary for coronary vascular development and activation of HH signaling is sufficient to promote coronary growth and to rescue coronary defects due to loss of FGF signaling, which implicate HH signaling as an essential regulator of coronary vascularDevelopment and as a potential therapeutic target for coronary neovascularization.

TL;DR: Human Etv2/ER71 and mouse ER71 proteins are identified as functional orthologs of Etsrp and it is demonstrated that the choice of endothelial versus myeloid fate depends on a combinatorial effect of etsRp, scl, and alk8 genes.

TL;DR: A key requirement for cell-autonomous EC FGFR signaling in injury-induced angiogenesis, but not for vascular homeostasis is revealed, identifying the ECFGFR signaling pathway as a target for diseases associated with aberrant vascular proliferation, such as age-related macular degeneration, and for modulating wound healing without the potential toxicity associated with direct manipulation of systemic FGF or VEGF activity.

TL;DR: In this paper, the identity of BM-derived lymphatic endothelial progenitor cells and their role in lymphatic neovascularization was investigated, and the podoplanin+ cells were isolated by magnetic-activated cell sorting.