C
Chantal Autexier
Researcher at McGill University
Publications - 82
Citations - 3637
Chantal Autexier is an academic researcher from McGill University. The author has contributed to research in topics: Telomerase & Telomere. The author has an hindex of 29, co-authored 79 publications receiving 3414 citations. Previous affiliations of Chantal Autexier include Cold Spring Harbor Laboratory & Jewish General Hospital.
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Journal ArticleDOI
The structure and function of telomerase reverse transcriptase
Chantal Autexier,Neal F. Lue +1 more
TL;DR: The structure and integrity of telomeres are essential for genome stability and regulation by RNA-DNA, TERT- DNA, Tert-RNA, TTERT interactions, and TERN-associated proteins; and the relationship between telomerase enzymology and telomere maintenance is discussed.
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Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing
François-Michel Boisvert,Jocelyn Côté,Marie-Chloé Boulanger,Patrick Cléroux,François Bachand,François Bachand,Chantal Autexier,Chantal Autexier,Stéphane Richard,Stéphane Richard +9 more
TL;DR: The findings support a model in which arginine methylation is important for the localization of coilin and SMN in Cajal bodies, and show that active spliceosomes contain sDMA polypeptides and suggest that arginin methylation was important for efficient pre-mRNA splicing.
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Telomerase and cancer: revisiting the telomere hypothesis
TL;DR: The original telomere hypothesis is refined to address the results of recent studies on telomerase and telomeres length regulation.
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A Platinum Supramolecular Square as an Effective G-Quadruplex Binder and Telomerase Inhibitor
Roxanne E. Kieltyka,Pablo Englebienne,Johans Fakhoury,Chantal Autexier,Nicolas Moitessier,Hanadi F. Sleiman +5 more
TL;DR: The potential of supramolecular self-assembly to readily generate scaffolds of unique geometries for effective targeting of G-quadruplexes and for the ultimate development of selective antitumor therapies is shown.
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Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.
TL;DR: A functional in vitro reconstitution assay of human telomerase RNA (hTR) was developed in this paper, where truncations at the 5' and 3' ends of hTR were identified as a functional region, similar in size to the full-length RNAs from ciliates.