N
Neal F. Lue
Researcher at Cornell University
Publications - 94
Citations - 5433
Neal F. Lue is an academic researcher from Cornell University. The author has contributed to research in topics: Telomere & Telomerase. The author has an hindex of 37, co-authored 87 publications receiving 5145 citations. Previous affiliations of Neal F. Lue include Johns Hopkins University School of Medicine & Stanford University.
Papers
More filters
Journal ArticleDOI
Cdc13p : A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
TL;DR: It is shown that CDC13 has two discrete roles at the telomere, with the use of two classes of mutations that perturbs a function required in vivo for telomerase regulation but not in vitro for enzyme activity.
Journal ArticleDOI
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
Courtney A. Lovejoy,Wendi Li,Steven Reisenweber,Supawat Thongthip,Joanne Bruno,Titia de Lange,Saurav De,John H.J. Petrini,Patricia Sung,Maria Jasin,Joseph Rosenbluh,Yaara Zwang,Yaara Zwang,Barbara A. Weir,Charlie Hatton,Elena Ivanova,Laura E. MacConaill,Megan Hanna,William C. Hahn,William C. Hahn,Neal F. Lue,Roger R. Reddel,Roger R. Reddel,Yuchen Jiao,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Alan K. Meeker +27 more
TL;DR: It is shown that loss of ATRX protein and mutations in the ATRRX gene are hallmarks of ALT–immortalized cell lines, and these attributes will facilitate the diagnosis and treatment ofALT positive human cancers.
Journal ArticleDOI
The structure and function of telomerase reverse transcriptase
Chantal Autexier,Neal F. Lue +1 more
TL;DR: The structure and integrity of telomeres are essential for genome stability and regulation by RNA-DNA, TERT- DNA, Tert-RNA, TTERT interactions, and TERN-associated proteins; and the relationship between telomerase enzymology and telomere maintenance is discussed.
Journal ArticleDOI
Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein.
TL;DR: The stimulatory effect of GRFI binding sites at UASs for the PYK1 and ENO1 genes is significantly enhanced by flanking DNA elements, which converts this region to a transcriptional silencer.
Journal ArticleDOI
Statistical positioning of nucleosomes by specific protein-binding to an upstream activating sequence in yeast.
TL;DR: Replacement of the upstream activation sequence by synthetic oligonucleotides with different protein-binding properties identified a short sequence within this region that is responsible for the ordered array.