C
Chao Xing
Researcher at University of Texas Southwestern Medical Center
Publications - 206
Citations - 11484
Chao Xing is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 38, co-authored 169 publications receiving 8895 citations. Previous affiliations of Chao Xing include Case Western Reserve University & Bristol-Myers Squibb.
Papers
More filters
Journal ArticleDOI
Prune belly syndrome in surviving males can be caused by Hemizygous missense mutations in the X-linked Filamin A gene
Nida S. Iqbal,Thomas A. Jascur,Steven M. Harrison,Steven M. Harrison,Angelena Edwards,Luke T. Smith,Erin S. Choi,Michelle K. Arevalo,Catherine Chen,Shaohua Zhang,Adam J. Kern,Angela E. Scheuerle,Emma Sanchez,Chao Xing,Linda A. Baker +14 more
TL;DR: This work identifies three unreported hemizygous missense point mutations in the X-chromosome gene Filamin A ( FLNA), the first evidence for an X-linked cause of PBS in multiple unrelated individuals and expands the phenotypic spectrum associated with FLNA in males surviving even into adulthood.
Journal ArticleDOI
A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud.
Caixia Xu,Xiaoming Yang,Hang Zhou,Yongyong Li,Chao Xing,Taifeng Zhou,Dongmei Zhong,Chengjie Lian,Mei Yan,Tao Chen,Zhiheng Liao,Bo Gao,Deying Su,Tingting Wang,Swarkar Sharma,Chandra Mohan,Nadav Ahituv,Sajid Malik,Quan Zhen Li,Peiqiang Su +19 more
TL;DR: The results identify the first PPD I disease-causing variant associated with enhancing SHH expression mediated by HnRNP K, which adds to the ZRS-associated syndromes classification system for PPD and clarifies the underlying molecular mechanisms.
Journal ArticleDOI
Distribution and magnitude of type I error of model‐based multipoint lod scores: implications for multipoint mod scores
Chao Xing,Robert C. Elston +1 more
TL;DR: In this paper, the authors study the distribution of multipoint lod scores both analytically and by simulation, and also study by simulation the maximum multipoint- lod scores when maximized over different penetrance models.
Journal ArticleDOI
SOX4-mediated repression of specific tRNAs inhibits proliferation of human glioblastoma cells.
Jianjing Yang,Derek K. Smith,Haoqi Ni,Haoqi Ni,Ke Wu,Dongdong Huang,Sishi Pan,Sishi Pan,Adwait Amod Sathe,Yu Tang,Meng Lu Liu,Chao Xing,Chun Li Zhang,Qichuan Zhuge +13 more
TL;DR: SOX4, a well-known Pol II-dependent transcription factor that is critical for neurogenesis and reprogramming of somatic cells, also directly controls, unexpectedly, the expression of a subset of tRNA genes and therefore protein synthesis and proliferation of human glioblastoma cells.
Posted ContentDOI
STING mediates immune responses in the closest living relatives of animals
TL;DR: In this article, the authors developed the choanoflagellate Monosiga brevicollis, one of the closest living relatives of animals, as a model for studying mechanisms underlying pathogen recognition and immune response.