C
Chao Xing
Researcher at University of Texas Southwestern Medical Center
Publications - 206
Citations - 11484
Chao Xing is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 38, co-authored 169 publications receiving 8895 citations. Previous affiliations of Chao Xing include Case Western Reserve University & Bristol-Myers Squibb.
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Journal ArticleDOI
The Use of Mebendazole in COVID-19 Patients: An Observational Retrospective Single Center Study
Mostafa W. Galal,Mahmoud H. Ahmed,Yanqiu Shao,Chao Xing,Wael G. Ali,Abd Elhamid Baly,A. Elfiky,Khaled Amer,John W. Schoggins,Hesham A. Sadek,Z Gobara +10 more
TL;DR: In this paper , an observational retrospective study of PCR-confirmed COVID-19 patients who received mebendazole with the intention-to-treat was conducted and the results showed that patients in the treatment group were 3.3 days closer to symptom resolution (P < 0.001).
Journal ArticleDOI
Basement membrane proteins in extracellular matrix characterize NF1 neurofibroma development and response to MEK inhibitor
TL;DR: In this article , the authors performed a systematic investigation of ECM enrichment during plexiform neurofibroma (pNF) development and identified basement membrane (BM) proteins, rather than major collagen isoforms, as the most upregulated ECM component.
Journal ArticleDOI
Autosomal recessive progeroid syndrome due to homozygosity for a TOMM7 variant
Abhimanyu Garg,Wee Teik Keng,Z. Chen,Adwait Amod Sathe,Chao Xing,P. D. Kailasam,Yanqiu Shao,Nicholas P. Lesner,Claire B. Llamas,Anil K. Agarwal,Prashant Ankur Jain Ved Kumar Mishra +10 more
TL;DR: It is concluded that altered mitochondrial protein import due to loss of function bi-allelic variant in TOMM7 can cause severe growth retardation and progeroid features.
Posted ContentDOI
Tau seeds translocate across the cell membrane to initiate aggregation
Dana A. Dodd,Michael LaCroix,Clarissa Valdez,Gregory M. Knox,Anthony R. Vega,Ashwani Kumar,Chao Xing,Charles I. White,Marc I. Diamond +8 more
TL;DR: Findings are most consistent with direct translocation of tau seeds across the lipid bilayer, a novel mechanism of entry into the cytoplasm, which is consistent with a primary role of endocytosis in tau uptake.