C
Chao Xing
Researcher at University of Texas Southwestern Medical Center
Publications - 206
Citations - 11484
Chao Xing is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 38, co-authored 169 publications receiving 8895 citations. Previous affiliations of Chao Xing include Case Western Reserve University & Bristol-Myers Squibb.
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Journal ArticleDOI
SAM homeostasis is regulated by CFIm- mediated splicing of MAT2A
Anna M. Scarborough,Juliana N Flaherty,Olga V. Hunter,Kuanqing Liu,Ashwani Kumar,Chao Xing,Benjamin P. Tu,Nicholas K. Conrad +7 more
TL;DR: Using an unbiased CRISPR knock-out screen, this paper identified CFIm25 (NUDT21) as a regulator of MAT2A intron detention and intracellular SAM levels.
Journal ArticleDOI
Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease.
Yongjun Chu,Jiaxin Hu,Hanquan Liang,Mohammed Kanchwala,Chao Xing,Walter Beebe,C Bradley Bowman,Xin Gong,David R. Corey,Venkateswara Mootha +9 more
TL;DR: RNA sequencing is used to compare tissue from individuals who are pre-symptomatic (Pre_S) to tissue from patients with late stage FECD (FECD_REP), finding gene candidates for early drivers of disease and biomarkers that may represent diagnostic and therapeutic targets for FECD.
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Identification of an IL-1-induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR− PCa cells
Shayna E. Thomas-Jardin,Mohammed Kanchwala,Joan Jacob,Sana Merchant,Rachel Meade,Nagham M. Gahnim,Afshan Fathima Nawas,Chao Xing,Nikki A. Delk +8 more
TL;DR: It is hypothesized that IL‐1 reprograms AR positive (AR+) PCa cells into AR negative (AR−)PCa cells that co‐optIL‐1 signaling to ensure AR‐independent survival and tumor progression in the inflammatory tumor microenvironment.
Journal ArticleDOI
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer
Shruthy Suresh,Deniz Durakoglugil,Xiaorong Zhou,Xiaorong Zhou,Bokai Zhu,Sarah A. Comerford,Chao Xing,Xian Jin Xie,Brian York,Kathryn A. O'Donnell +9 more
TL;DR: It is suggested that SRC-2 may exhibit oncogenic or tumor suppressor activity depending on the target genes and nuclear receptors that are expressed in distinct tissues and illuminate the mechanisms of tumor suppression by Src-2 in liver.
Posted ContentDOI
STING mediates immune responses in a unicellular choanoflagellate
TL;DR: In this paper, the authors developed the choanoflagellate Monosiga brevicollis, one of the closest living relatives of animals, as a model for studying mechanisms underlying pathogen recognition and immune response.