Renée M. McKay

TL;DR: A relatively quiescent subset of endogenous glioma cells, with properties similar to those proposed for cancer stem cells, is responsible for sustaining long-term tumour growth through the production of transient populations of highly proliferative cells.

TL;DR: It is shown that some ccRCCs are HIF-2 independent, and set the stage for biomarker-driven clinical trials, using a tumourgraft/patient-derived xenograft platform to evaluate PT2399, a selective Hif-2 antagonist that was identified using a structure-based design approach.

TL;DR: How recent sequencing studies are identifying unexpected drivers of gliomagenesis is discussed, including mutations in isocitrate dehydrogenase 1 and the NF-κB pathway, and how genome-wide analyses are reshaping the classification schemes for tumors and enhancing prognostic value of molecular markers are discussed.

TL;DR: Data indicate that CKI may be a conserved component of the Wnt pathway, which was isolated by expression cloning in Xenopus embryos andhibiting CKI in Caenorhabditis elegans generated worms with a mom phenotype, indicative of a loss of Wnt signals.

TL;DR: Data suggest that C. elegans is a genetically tractable model to study the mechanisms that underlie the biology of fat-storing tissues and identifies several additional genes that play a role in worm lipid storage.