C
Chaoqun Chen
Researcher at Yale University
Publications - 1
Citations - 1611
Chaoqun Chen is an academic researcher from Yale University. The author has contributed to research in topics: Innate immune system & Receptor. The author has an hindex of 1, co-authored 1 publications receiving 1551 citations.
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MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Ruslan Medzhitov,Paula Preston-Hurlburt,Elizabeth Kopp,Andrew Stadlen,Chaoqun Chen,Sankar Ghosh,Charles A. Janeway +6 more
TL;DR: MyD88 is implicate as a general adaptor/regulator molecule for the Toll/IL-1R family of receptors for innate immunity and induces activation of NF-kappaB via the Pelle-like kinase IRAK and the TRAF6 protein, similar to IL- 1R-mediated NF- kappaB activation.