Showing papers in "Molecular Cell in 1998"

TL;DR: The genome-wide characterization of mRNA transcript levels during the cell cycle of the budding yeast S. cerevisiae indicates a mechanism for local chromosomal organization in global mRNA regulation and links a range of human genes to cell cycle period-specific biological functions.

TL;DR: The cloning of p63, a gene at chromosome 3q27-29 that bears strong homology to the tumor suppressor p53 and to the related gene, p73, is described and the possibility of physiological interactions among members of the p53 family is suggested.

TL;DR: A crucial role for this protein in the development or function of the kidney filtration barrier is demonstrated and by Northern and in situ hybridization was shown to be specifically expressed in renal glomeruli.

TL;DR: Monocyte chemoattractant protein-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder.

TL;DR: MyD88 is implicate as a general adaptor/regulator molecule for the Toll/IL-1R family of receptors for innate immunity and induces activation of NF-kappaB via the Pelle-like kinase IRAK and the TRAF6 protein, similar to IL- 1R-mediated NF- kappaB activation.

TL;DR: The ASH1 3'UTR-dependent particle serves as a marker for RNA transport and localization, and the SHE mutants disrupt RNA and particle localization and SHE 2 and 3 mutants inhibit particle formation.

TL;DR: Phosphorylation by PKA both weakens the interaction between the N- and C-terminal regions of p65 and creates an additional site for interaction with CBP/p300, which regulates the transcriptional activity of NF-kappa B by modulating its interaction withCBP/ p300.

TL;DR: It is shown that deletion of the Apaf-1 WD-40 repeats makes Apf-1 constitutively active and capable of processing procaspase-9 independent of cytochrome c/dATP and oligomerizing its precursor molecules.

TL;DR: Insulin resistance in muscle contributes to the altered fat metabolism associated with type 2 diabetes, but tissues other than muscle appear to be more involved in insulin-regulated glucose disposal than previously recognized.

TL;DR: SOCS-3 is a leptin-inducible inhibitor of leptin signaling, and a potential mediator of leptin resistance in Obesity, a model of leptin-resistant murine obesity.

TL;DR: The results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin.

TL;DR: The reconstitution of an eIF4E/eIF4G/Pab1p complex with recombinant proteins is demonstrated and it is shown that the complex can circularize capped, polyadenylated RNA, suggesting that formation of circular mRNA by translation factors could contribute to the control of mRNA expression in the eukaryotic cell.

TL;DR: In this article, a modified IkappaBalpha, conjugated to the small ubiquitin-like protein SUMO-1, which is resistant to signal-induced degradation, was detected.

TL;DR: This work has investigated the enzymatic activities of the purified proteins and found that Mre11 by itself has 3' to 5' exonuclease activity that is increased when Mre 11 is in a complex with Rad50, which is consistent with the products of nonhomologous end-joining observed in vivo.

TL;DR: A novel DNA damage recognition-competition assay is used to identify XPC-HR23B as the earliest damage detector to initiate NER: it acts before the known damage-binding protein XPA, providing a plausible explanation for the extreme damage specificity exhibited by global genome repair.

TL;DR: The data suggest that the PPAR gamma transcriptional pathway can induce terminal differentiation of malignant breast epithelial cells and thus may provide a novel, nontoxic therapy for human breast cancer.

TL;DR: This work shows that the Cdc14 phosphatase triggers mitotic exit by three parallel mechanisms, each of which inhibits Cdk activity, and induces degradation of mitotic cyclins.

TL;DR: It is proposed that Sml1 inhibits dNTP synthesis posttranslationally by binding directly to Rnr1 and that Mec1 and Rad53 are required to relieve this inhibition.

TL;DR: The results suggest a role for PIX in Cdc42-to-Rac1 signaling, involving the PIX/PAK complex, and a new class of Rho-p21 guanine nucleotide exchange factor binding tightly through its N-terminal SH3 domain to a conserved proline-rich PAK sequence with a Kd of 24 nM.

TL;DR: A virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes and is a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo.

TL;DR: It is reported that activation of the two transcription factors NF-kappa B and AP-1 is crucially involved in FasL expression induced by etoposid, teniposide, and UV irradiation and contributes to stress-induced apoptosis via the expression of FasL.

TL;DR: HIV-1 Vpu interacts with CD4 in the endoplasmic reticulum and triggers CD4 degradation, presumably by proteasomes, and beta TrCP identified by interaction with Vpu connects CD4 to this proteolytic machinery, and CD4-Vpu-beta TrCP ternary complexes have been detected by coimmunoprecipitation.

TL;DR: Gremlin belongs to a novel gene family that includes the head-inducing factor Cerberus and the tumor suppressor DAN and it is proposed that Gremlin, Cerberus, and DAN control diverse processes in growth and development by selectively antagonizing the activities of different subsets of the TGF beta ligands.

TL;DR: It is reported that trehalose stabilizes proteins in yeast cells during heat shock and suppresses the aggregation of denatured proteins, maintaining them in a partially-folded state from which they can be activated by molecular chaperones.

TL;DR: It is shown that ASK1 interacts with members of the TRAF family and is activated by TRAF2, TRAF5, and TRAF6 overexpression and is a mediator of TRAf2-induced JNK activation.

TL;DR: This work reports a patient with a lesion of the superior parietal lobe who shows both sensory and motor deficits consistent with an inability to maintain such an internal representation of the body's state between updates, and suggests that the superior Parietal lobe is critical for sensorimotor integration.

TL;DR: It is demonstrated that the NS1 effector domain functionally interacts with the cellular 30 kDa subunit of CPSF, an essential component of the 3' end processing machinery of cellular pre-mRNAs.

TL;DR: BRCA1 and BRCA2 participate, together, in a pathway(s) associated with the activation of double-strand break repair and/or homologous recombination and Dysfunction of this pathway may be a general phenomenon in the majority of cases of hereditary breast and/ or ovarian cancer.

TL;DR: In this article, the authors made simultaneous recordings from three classes of neurons in cortical layer 2/3, and induced repetitive action potentials in pyramidal cells and recorded the evoked unitary excitatory (E)PSPs in two classes of GABAergic neurons.

TL;DR: It is shown that COP1 negatively regulates HY5, a bZIP protein and a positive regulator of photomorphogenic development, and proposed that the direct interaction with and regulation of transcription factors by COP1 may represent the molecular mechanism for its control of gene expression and photomorphic development.