P
Paula Preston-Hurlburt
Researcher at Yale University
Publications - 37
Citations - 10230
Paula Preston-Hurlburt is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 19, co-authored 33 publications receiving 9678 citations.
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Journal ArticleDOI
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
Journal ArticleDOI
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Ruslan Medzhitov,Paula Preston-Hurlburt,Elizabeth Kopp,Andrew Stadlen,Chaoqun Chen,Sankar Ghosh,Charles A. Janeway +6 more
TL;DR: MyD88 is implicate as a general adaptor/regulator molecule for the Toll/IL-1R family of receptors for innate immunity and induces activation of NF-kappaB via the Pelle-like kinase IRAK and the TRAF6 protein, similar to IL- 1R-mediated NF- kappaB activation.
Journal ArticleDOI
Sequence analysis of peptides bound to MHC class II molecules
Alexander Y. Rudensky,Paula Preston-Hurlburt,Soon-Cheol Hong,Avlin K. Barlow,Charles A. Janeway +4 more
TL;DR: The finding of predominant self peptides has interesting implications for antigen processing and self–non-self discrimination.
Journal ArticleDOI
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients.
Carl A. Pierce,Paula Preston-Hurlburt,Yile Dai,Clare Burn Aschner,Natalia Cheshenko,Benjamin T. Galen,Scott J. Garforth,Natalia G. Herrera,Rohit K. Jangra,Nicholas C. Morano,Erika P. Orner,Sharlene Sy,Kartik Chandran,James Dziura,Steven C. Almo,Aaron M. Ring,Marla J. Keller,Kevan C. Herold,Betsy C. Herold +18 more
TL;DR: The findings suggest that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses, and age-dependent factors may modulate the antiviral immune response.
Journal ArticleDOI
On the complexity of self.
Alexander Y. Rudensky,Satyajit Rath,Paula Preston-Hurlburt,Donal B. Murphy,Donal B. Murphy,Charles A. Janeway +5 more
TL;DR: Data suggest that self peptides presented by self MHC class II molecules at densities sufficient to signal a CD4 T cell are of very limited complexity, as Y-Ae stains antigen presenting cells that mediate negative selection but not thymic cortical epithelial cells5 that drive positive selection3.