Chaoyun Pan

TL;DR: A non-metabolic function of PKM2, an enzyme associated with tumours cell reliance on aerobic glycolysis, in promoting tumour cell exosome release is revealed.

TL;DR: The role of identified microRNAs in controlling SIRPα synthesis in leukocytes and leukocyte inflammatory responses was determined in this paper, showing that miR-17, miR20a, and miR106a specifically bound to the same seed sequence within the 3' untranslated region and correlated inversely with SIRpα protein levels in various cells.

TL;DR: It is reported that HCMV reprogrammes human haematopoietic progenitor cells into a unique monocyte subset to achieve latency, which possesses higher levels of B7-H4, IL-10 and inducible nitric oxide synthase, a longer lifespan and strong immunosuppressive capacity.

TL;DR: Mechanistically, it is shown that CDC25B plays an important role in suppressing HCMV IE1 and lytic gene transcription by activating cyclin-dependent kinase 1 (CDK-1) and both gain-of-function and lose- of-function assays demonstrated that miR-UL148D promotes H CMV latency by helping maintain CDC 25B activity in host cells.

TL;DR: Serum HCMV-miR-US4-1 can serve as a novel biomarker for predicting the outcome of IFNα treatment in CHB patients and is demonstrated to be a good indicator for interferon α treatment.