Lei Shi

TL;DR: A non-metabolic function of PKM2, an enzyme associated with tumours cell reliance on aerobic glycolysis, in promoting tumour cell exosome release is revealed.

TL;DR: The role of identified microRNAs in controlling SIRPα synthesis in leukocytes and leukocyte inflammatory responses was determined in this paper, showing that miR-17, miR20a, and miR106a specifically bound to the same seed sequence within the 3' untranslated region and correlated inversely with SIRpα protein levels in various cells.

TL;DR: The present study reveals that macrophage phagocytosis toward healthy self-cells is controlled by a two-tier mechanism: a forefront activation mechanism requiring the inflammatory cytokine-stimulated protein kinase C (PKC)-spleen tyrosine kinase (Syk) pathway, and the subsequent self-target discrimination mechanism controlled by the CD47-signal regulatory protein α (SIRPα)–mediated inhibition.

TL;DR: This study reveals that CD47 normally is clustered in lipid rafts on nonapoptotic cells but is diffused in the plasma membrane when apoptosis occurs; this transformation of CD47 greatly reduces the strength ofCD47–SIRPα engagement, resulting in the phagocytosis of apoptotic cells.

TL;DR: Surprisingly, the study indicates that induction of arginase‐1 expression is not conducive to the critical MDSC‐mediated inhibition toward T cells, which is rather dependent on direct cell contacts undiminished by PD‐L1 blockade or SIRPα deficiency.