X
Xi Chen
Researcher at Nanjing University
Publications - 222
Citations - 15749
Xi Chen is an academic researcher from Nanjing University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 59, co-authored 204 publications receiving 12888 citations. Previous affiliations of Xi Chen include Nanjing Medical University & Nankai University.
Papers
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Journal ArticleDOI
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: Evidence of cross-kingdom regulation by microRNA
Lin Zhang,Dongxia Hou,Xi Chen,Donghai Li,Lingyun Zhu,Lingyun Zhu,Yujing Zhang,Jing Li,Zhen Bian,Xiangying Liang,Xing Cai,Yuan Yin,Cheng Wang,Tianfu Zhang,Dihan Zhu,Dianmu Zhang,Jie Xu,Qun Chen,Yi Ba,Jing Liu,Qiang Wang,Jian-Qun Chen,Jin Wang,Meng Wang,Qipeng Zhang,Junfeng Zhang,Ke Zen,Chen-Yu Zhang +27 more
TL;DR: It is shown that MIR168a could bind to the human/mouse low-density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma, demonstrating that exogenous plant miRNAs in food can regulate the expression of target genes in mammals.
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Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non–Small-Cell Lung Cancer
Zhibin Hu,Xi Chen,Yang Zhao,Tian Tian,Guangfu Jin,Yongqian Shu,Yijiang Chen,Lin Xu,Ke Zen,Chen-Yu Zhang,Hongbing Shen +10 more
TL;DR: The four-miRNA signature from the serum may serve as a noninvasive predictor for the overall survival of NSCLC.
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Secreted microRNAs: a new form of intercellular communication.
TL;DR: A possible working model for how secreted miRNAs might be sorted and transferred between cells are proposed and speculated on their biological significance are proposed.
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Role of miR-143 targeting KRAS in colorectal tumorigenesis
Xi Chen,Xing Guo,Haitian Zhang,Haitian Zhang,Yang Xiang,Jian-Qun Chen,Yin Yin,Xing Cai,Kehui Wang,G. Wang,Yi Ba,Lingyun Zhu,Jin Wang,Ruigang Yang,Yujing Zhang,Zhiji Ren,Ke Zen,Junfeng Zhang,Chen-Yu Zhang +18 more
TL;DR: The present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation.
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Serum microRNA Profiles Serve as Novel Biomarkers for HBV Infection and Diagnosis of HBV-Positive Hepatocarcinoma
Limin Li,Zhibin Hu,Zhenxian Zhou,Xi Chen,Fenyong Liu,Junfeng Zhang,Hongbing Shen,Chen-Yu Zhang,Ke Zen +8 more
TL;DR: This study demonstrates for the first time that serum miRNA profiles can serve as novel and noninvasive biomarkers for HBV infection and HBV-positive HCC diagnosis.