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Chen-Yu Zhang
Researcher at Nanjing University
Publications - 357
Citations - 44401
Chen-Yu Zhang is an academic researcher from Nanjing University. The author has contributed to research in topics: microRNA & Gene silencing. The author has an hindex of 85, co-authored 332 publications receiving 39724 citations. Previous affiliations of Chen-Yu Zhang include Beth Israel Deaconess Medical Center & Tianjin Medical University Cancer Institute and Hospital.
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Journal ArticleDOI
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
Xi Chen,Yi Ba,Lijia Ma,Lijia Ma,Xing Cai,Yuan Yin,Kehui Wang,Jigang Guo,Yujing Zhang,Jiangning Chen,Xing Guo,Qibin Li,Qibin Li,Xiaoying Li,Wenjing Wang,Yan Zhang,Jin Wang,Xueyuan Jiang,Yang Xiang,Chen Xu,Pingping Zheng,Juanbin Zhang,Ruiqiang Li,Hongjie Zhang,Xiaobin Shang,Ting Gong,Guang Ning,Jun Wang,Jun Wang,Ke Zen,Junfeng Zhang,Chen-Yu Zhang +31 more
TL;DR: It is demonstrated that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses, and can serve as potential biomarkers for the detection of various cancers and other diseases.
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Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
Zhidan Wu,Pere Puigserver,Ulf Andersson,Chen-Yu Zhang,Guillaume Adelmant,Vamsi K. Mootha,Amy E Troy,Saverio Cinti,Bradford B. Lowell,Richard C. Scarpulla,Bruce M. Spiegelman +10 more
TL;DR: PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs).
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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Jiandie D. Lin,Hai Wu,Paul T. Tarr,Chen-Yu Zhang,Zhidan Wu,Olivier Boss,Laura F. Michael,Pere Puigserver,Elji Isotani,Eric N. Olson,Bradford B. Lowell,Rhonda S Bassel-Duby,Bruce M. Spiegelman +12 more
TL;DR: Using fibre-type-specific promoters, it is shown in cultured muscle cells that PGC-1α activates transcription in cooperation with Mef2 proteins and serves as a target for calcineurin signalling, which has been implicated in slow fibre gene expression.
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Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Jiandie D. Lin,Pei Hsuan Wu,Paul T. Tarr,Katrin S. Lindenberg,Julie St-Pierre,Chen-Yu Zhang,Vamsi K. Mootha,Sibylle Jäger,Claudia R. Vianna,Richard M. Reznick,Libin Cui,Monia Manieri,Mi X. Donovan,Zhidan Wu,Marcus P. Cooper,Melina C. Fan,Lindsay M. Rohas,Ann Marie Zavacki,Saverio Cinti,Gerald I. Shulman,Bradford B. Lowell,Dimitri Krainc,Bruce M. Spiegelman +22 more
TL;DR: A central role for PGC-1alpha in the control of energy metabolism is illustrated but also novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis are revealed.
Journal ArticleDOI
Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration
Yujing Zhang,Dan-Qing Liu,Xi Chen,Jing Li,Limin Li,Zhen Bian,Fei Sun,Jiuwei Lu,Yuan Yin,Xing Cai,Qi Sun,Kehui Wang,Yi Ba,Qiang Wang,Dongjin Wang,Junwei Yang,Pingsheng Liu,Tao Xu,Qiao Yan,Junfeng Zhang,Ke Zen,Chen-Yu Zhang +21 more
TL;DR: It is reported that secreted miRNAs can serve as signaling molecules mediating intercellular communication and demonstrate that cells can secrete miRNA and deliver them into recipient cells where the exogenous mi RNAs can regulate target gene expression and recipient cell function.